Hayes Jennifer H, Anderson Kristin E, Folsom Aaron R
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Suite 300, 1300 South Second Street, Minneapolis, MN 55454-1015, USA.
Cancer Epidemiol Biomarkers Prev. 2006 Nov;15(11):2226-31. doi: 10.1158/1055-9965.EPI-06-0172.
Previous studies have suggested that use of aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) may be associated with reduced risk of lung cancer, but the data are inconsistent and are limited particularly with respect to the effects of aspirin, separate from other NSAIDs.
The Iowa Women's Health Study is a prospective cohort of 41,836 Iowa women ages 55 to 69 years old at baseline in 1986. NSAID use was assessed in 1992. Over 10 years of follow-up, 403 incident cases of lung cancer were identified. The association of incident lung cancer with current use of aspirin or non-aspirin NSAIDs was analyzed after adjustment for lung cancer risk factors. Hazard ratios (HR) were estimated using multivariate COX proportional hazards regression.
There were 27,162 women in the analytic cohort. After controlling for age, education, alcohol intake, pack-years, smoking status, body mass index, and total fruit intake, the RR of women taking six or more aspirin weekly was 1.21 (95% confidence interval, 0.92-1.59). The HR was 1.23 for women taking six or more non-aspirin NSAIDs weekly (95% confidence interval, 0.92-1.65). There was no statistically significant trend by frequency of use for either aspirin (P(trend) = 0.22) or non-aspirin NSAIDs (P(trend) = 0.53). Analyses by histologic type and smoking status yielded similar null results. Information on dosage and duration of use were not available for this analysis.
These findings do not suggest that aspirin or other NSAIDs reduce risk of lung cancer in this cohort of postmenopausal women.
既往研究表明，使用阿司匹林或其他非甾体抗炎药（NSAIDs）可能与肺癌风险降低有关，但数据并不一致，特别是关于阿司匹林单独使用（与其他NSAIDs分开）的效果方面的数据有限。
爱荷华妇女健康研究是一个前瞻性队列研究，1986年基线时纳入了41,836名年龄在55至69岁之间的爱荷华州妇女。1992年评估了NSAIDs的使用情况。在超过10年的随访中，确定了403例肺癌新发病例。在对肺癌风险因素进行调整后，分析了肺癌新发病例与当前使用阿司匹林或非阿司匹林NSAIDs之间的关联。使用多变量COX比例风险回归估计风险比（HR）。
分析队列中有27,162名女性。在控制年龄、教育程度、酒精摄入量、吸烟包年数、吸烟状态、体重指数和水果总摄入量后，每周服用六片或更多阿司匹林的女性的相对风险（RR）为1.21（95%置信区间，0.92 - 1.59）。每周服用六片或更多非阿司匹林NSAIDs的女性的HR为1.23（95%置信区间，0.92 - 1.65）。阿司匹林（P趋势 = 0.22）或非阿司匹林NSAIDs（P趋势 = 0.53）的使用频率均无统计学显著趋势。按组织学类型和吸烟状态进行的分析得出了类似的阴性结果。该分析没有关于使用剂量和持续时间的信息。
这些发现并不表明阿司匹林或其他NSAIDs能降低该绝经后女性队列中的肺癌风险。
