Trofatter K F
Department of Obstetrics and Gynecology, University of Tennessee Medical Center, Knoxville.
Dermatol Clin. 1991 Apr;9(2):343-52.
Because of their antiviral, antiproliferative, and immunoregulatory properties, IFNs are potentially well suited for use in the management of benign HPV-related anogenital diseases. Parenteral and intralesional therapy of condylomata with various natural and recombinant IFN preparations has consistently resulted in beneficial response rates ranging between 40% and 60%, often in patients in whom other therapeutic measures have repeatedly failed. Adverse effects from IFN are dose dependent and generally tolerable at concentrations of IFN found to be effective in the treatment of condylomata, and they are not associated with any known long-term sequelae. When combined with conventional medical and surgical treatment modalities, IFN offers real promise for the control of both extensive primary and recalcitrant HPV-related conditions.
由于具有抗病毒、抗增殖和免疫调节特性，干扰素在治疗良性人乳头瘤病毒（HPV）相关的肛门生殖器疾病方面可能非常适用。使用各种天然和重组干扰素制剂对尖锐湿疣进行肠胃外和病灶内治疗，始终能产生40%至60%的有效反应率，而且通常是在其他治疗措施反复失败的患者中取得这样的效果。干扰素的不良反应具有剂量依赖性，在治疗尖锐湿疣有效的干扰素浓度下一般是可耐受的，并且不会产生任何已知的长期后遗症。当与传统的医学和外科治疗方法联合使用时，干扰素对于控制广泛的原发性和难治性HPV相关病症确实很有前景。
