Parolin Mônica Beatriz, Réa Rosângela, Vargas Rosa Maria, de Almeida Ana Cristina Ravazzani, Baldanzi Giorgio Roberto, Lopes Reginaldo Werneck
Serviço de Transplante Hepático, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR.
Arq Gastroenterol. 2006 Apr-Jun;43(2):77-80. doi: 10.1590/s0004-28032006000200003.
Recently, a possible epidemiological association between hepatitis C virus infection and diabetes mellitus has been suggested and a higher prevalence of HCV antibodies has been found among type 2 diabetic when compared with normal controls.
To evaluate the prevalence of hepatitis C infection in diabetic patients in Curitiba, PR, Brazil.
A total of 145 type 2 and 104 type 1 diabetic patients attending the outpatient diabetic unit of an university hospital were consecutively tested for anti-HCV, using a fourth-generation enzyme-linked immunosorbent assay (ELISA). The control group was constituted by 16,720 volunteer blood donors attending the blood bank of the same hospital during the period of the study. Diabetic patients were also evaluated for clinical, biochemical (aminotransferase levels) and demographic variables and previous exposure to risk factors for hepatitis C infection.
A higher prevalence of hepatitis C infection was observed in type 2 diabetic patients in comparison with blood donors. Although anti-HCV prevalence in type 2 diabetic patients was higher than found in type 1, it did not reach statistical significance. Both diabetic groups were predominantly female, and as expected, type 2 diabetic were older than type 1. Race distribution, duration of the disease, and previous exposure to hepatitis C risk factors were similar in both groups, but type 2 diabetic subjects had higher median levels of alanine aminotransferase than type 1.
A higher prevalence of hepatitis C infection was detected in type 2 diabetic patients in comparison with blood donors in our region, in accordance with study data from different populations. If all type 2 diabetic patients should undergo regular screening for hepatitis C infection remains a question.
最近，有人提出丙型肝炎病毒感染与糖尿病之间可能存在流行病学关联，并且与正常对照组相比，2型糖尿病患者中丙型肝炎病毒抗体的患病率更高。
评估巴西巴拉那州库里蒂巴市糖尿病患者中丙型肝炎感染的患病率。
使用第四代酶联免疫吸附测定（ELISA），对一家大学医院门诊糖尿病科的145例2型糖尿病患者和104例1型糖尿病患者连续进行抗丙型肝炎病毒检测。对照组由研究期间在同一家医院血库献血的16720名志愿者组成。还对糖尿病患者进行了临床、生化（转氨酶水平）和人口统计学变量以及既往丙型肝炎感染危险因素暴露情况的评估。
与献血者相比，2型糖尿病患者中丙型肝炎感染的患病率更高。虽然2型糖尿病患者的抗丙型肝炎病毒患病率高于1型糖尿病患者，但未达到统计学意义。两个糖尿病组均以女性为主，正如预期的那样，2型糖尿病患者比1型糖尿病患者年龄更大。两组的种族分布、病程以及既往丙型肝炎危险因素暴露情况相似，但2型糖尿病患者的丙氨酸转氨酶中位数水平高于1型糖尿病患者。
与本地区的献血者相比，2型糖尿病患者中丙型肝炎感染的患病率更高，这与不同人群的研究数据一致。所有2型糖尿病患者是否都应定期进行丙型肝炎感染筛查仍是一个问题。
