Serviço de Endocrinologia, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2350, Porto Alegre, RS, Brazil.
Braz J Med Biol Res. 2012 Mar;45(3):284-90. doi: 10.1590/s0100-879x2012007500013. Epub 2012 Feb 2.
The objective of the present cross-sectional study was to assess the prevalence and the clinical and laboratory features of hepatitis C virus (HCV)-positive patients with type 2 diabetes mellitus (DM) attending either an outpatient clinic or hemodialysis units. Serologic-HCV testing was performed in 489 type 2 DM patients (303 outpatients and 186 on dialysis). A structured assessment of clinical, laboratory and DM-related complications was performed and the patients were then compared according to HCV infection status. Mean patient age was 60 years; HCV positivity (HCV+) was observed in 39 of 303 (12.9%) outpatients and in 34 of 186 (18.7%) dialysis patients. Among HCV+ patients, 32 were men (43.8%). HCV+ patients had higher serum levels of aspartate aminotransferase (0.90 ± 0.83 vs 0.35 ± 0.13 µKat/L), alanine aminotransferase (0.88 ± 0.93 vs 0.38 ± 0.19 µKat/L), gamma-glutamyl transferase (1.57 ± 2.52 vs 0.62 ± 0.87 µKat/L; P < 0.001), and serum iron (17.65 ± 6.68 vs 14.96 ± 4.72 µM; P = 0.011), and lower leukocyte and platelet counts (P = 0.010 and P < 0.001, respectively) than HCV-negative (HCV-) patients. HCV+ dialysis patients had higher diastolic blood pressure than HCV- patients (87.5 ± 6.7 vs 81.5 ± 6.0 mmHg; P = 0.005) and a lower prevalence of diabetic retinopathy (75 vs 92.7%; P = 0.007). In conclusion, our study showed that HCV is common among subjects with type 2 DM but is not associated with a higher prevalence of chronic diabetic complications.
本横断面研究的目的是评估在门诊或血液透析单位就诊的 2 型糖尿病（DM）合并丙型肝炎病毒（HCV）阳性患者的患病率及临床和实验室特征。对 489 名 2 型 DM 患者（303 名门诊患者和 186 名透析患者）进行血清 HCV 检测。对临床、实验室和 DM 相关并发症进行了结构化评估，并根据 HCV 感染状态对患者进行了比较。患者平均年龄为 60 岁；303 名门诊患者中有 39 名（12.9%）和 186 名透析患者中有 34 名（18.7%）为 HCV 阳性（HCV+）。在 HCV+患者中，有 32 名男性（43.8%）。HCV+患者血清天门冬氨酸氨基转移酶（0.90±0.83 vs 0.35±0.13 µKat/L）、丙氨酸氨基转移酶（0.88±0.93 vs 0.38±0.19 µKat/L）、γ-谷氨酰转肽酶（1.57±2.52 vs 0.62±0.87 µKat/L；P＜0.001）和血清铁（17.65±6.68 vs 14.96±4.72 µM；P=0.011）水平较高，白细胞和血小板计数较低（P=0.010 和 P＜0.001），与 HCV-患者相比。HCV+透析患者的舒张压高于 HCV-患者（87.5±6.7 vs 81.5±6.0 mmHg；P=0.005），且糖尿病视网膜病变的患病率较低（75 vs 92.7%；P=0.007）。总之，我们的研究表明，2 型 DM 患者中 HCV 很常见，但与慢性糖尿病并发症的高患病率无关。
