Lu Pengfei, Sternlicht Mark D, Werb Zena
Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, CA 94143-0452, USA.
J Mammary Gland Biol Neoplasia. 2006 Oct;11(3-4):213-28. doi: 10.1007/s10911-006-9027-z.
Much progress has been made in recent years toward understanding mechanisms controlling branching morphogenesis, a fundamental aspect of development in a variety of invertebrate and vertebrate organs. To gain a deeper understanding of how branching morphogenesis occurs in the mammary gland, we compare and contrast the cellular and molecular events underlying this process in both invertebrate and vertebrate organs. Thus, in this review, we focus on the common themes that have emerged from such comparative analyses and discuss how they are implemented via a battery of signaling pathways to ensure proper branching morphogenesis in diverse systems.
近年来,在理解控制分支形态发生的机制方面取得了很大进展,分支形态发生是各种无脊椎动物和脊椎动物器官发育的一个基本方面。为了更深入地了解乳腺中分支形态发生是如何发生的,我们比较并对比了无脊椎动物和脊椎动物器官中这一过程背后的细胞和分子事件。因此,在本综述中,我们关注此类比较分析中出现的共同主题,并讨论它们是如何通过一系列信号通路来实现的,以确保在不同系统中正确的分支形态发生。