Rivkin I, Becker E L
Int Arch Allergy Appl Immunol. 1976;50(1):95-102. doi: 10.1159/000231485.
Cyclic AMP placed in the bottom of the modified Boyden chemotaxis chamber is weakly chemotactic for rabbit peritoneal neutrophils. Dibutyryl-cyclic AMP under similar conditions gives a biphasic response, being weakly chemotactic at low concentrations and inhibiting cell movement at higher concentrations. When mixed with the cells in the upper compartment of the chemotaxis chamber, cyclic AMP and dibutyryl-cyclic AMP enhance neutrophil spontaneous motility; on the other hand, dibutyryl-cyclic AMP mixed with the cells in the upper compartment consistently inhibits neutrophil chemotactic responsiveness, while cyclic AMP has a variable effect on chemotaxis. The effect of ADP and ATP was to inhibit chemotaxis and spontaneous motility. AMP is totally without effect.
置于改良的博伊登趋化性小室底部的环磷酸腺苷（Cyclic AMP）对兔腹膜中性粒细胞具有微弱的趋化作用。在类似条件下，二丁酰环磷酸腺苷（Dibutyryl-cyclic AMP）呈现双相反应，低浓度时具有微弱的趋化作用，高浓度时则抑制细胞运动。当环磷酸腺苷和二丁酰环磷酸腺苷与趋化性小室上室中的细胞混合时，它们会增强中性粒细胞的自发运动性；另一方面，与上室中的细胞混合的二丁酰环磷酸腺苷始终抑制中性粒细胞的趋化反应性，而环磷酸腺苷对趋化性的影响则各不相同。二磷酸腺苷（ADP）和三磷酸腺苷（ATP）的作用是抑制趋化性和自发运动性。单磷酸腺苷（AMP）则完全没有作用。
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