毛细管多形核细胞迁移的刺激：糖皮质激素对微管功能的间接作用。
Stimulation of capillary tube polymorph migration: an indirect glucocorticoid effect on microtubular function.
作者信息
Stevenson R D, Gray A C, Lucie N P
出版信息
Clin Exp Immunol. 1978 Sep;33(3):478-85.
Polymorph migration stimulator (PMS) is a peptide factor produced by an in vitro reaction between glucocorticoids and human mononuclear phagocytes. This study was undertaken to determine the significance of the stimulatory effect of PMS on the capillary tube migration of human polymorphs. Colchicine, vinblastine and Nocodazole, all of which inhibit microtubular assembly, are shown to stimulate migration. Conversely, deuterium oxide which stabilizes microtubules inhibits migration. Increased intracellular cyclic AMP is associated with microtubular inhibition and isoprenaline, theophylline and dibutyryl cyclic AMP are also found to stimulate capillary tube migration. These results suggest that PMS acts by inhibiting the assembly of polymorph microtubules, an effect which may be mediated by cyclic AMP in the same manner as other peptide hormones.
多形核白细胞迁移刺激因子（PMS）是糖皮质激素与人单核吞噬细胞体外反应产生的一种肽因子。本研究旨在确定PMS对人多形核白细胞毛细管迁移刺激作用的意义。秋水仙碱、长春碱和诺考达唑均能抑制微管组装，结果显示它们能刺激迁移。相反，稳定微管的氧化氘则抑制迁移。细胞内环状AMP增加与微管抑制有关，并且还发现异丙肾上腺素、茶碱和二丁酰环状AMP能刺激毛细管迁移。这些结果表明，PMS通过抑制多形核白细胞微管的组装起作用，这种作用可能与其他肽类激素一样由环状AMP介导。
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