Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Mar Drugs. 2017 Sep 29;15(10):300. doi: 10.3390/md15100300.
New lobane-based diterpenoids lobovarols A-D (-) and a prenyleudesmane-type diterpenoid lobovarol E () along with seven known related diterpenoids (-) were isolated from the ethyl acetate extract of a Taiwanese soft coral . Their structures were identified on the basis of multiple spectroscopic analyses and spectral comparison. The absolute configuration at C-16 of the known compound is reported herein for the first time. The anti-inflammatory activities of compounds - were assessed by measuring their inhibitory effect on -formyl-methionyl-leucyl-phenyl-alanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release in human neutrophils. Metabolites , , and were found to show moderate inhibitory activity on the generation of superoxide anion, while compounds , , , and could effectively suppress elastase release in fMLP/CB-stimulated human neutrophil cells at 10 μM. All of the isolated diterpenoids did not exhibit cytotoxic activity (IC > 50 μM) towards a limited panel of cancer cell lines.
从台湾软珊瑚中分离得到了新的基于 lobane 的二萜类化合物 lobovarols A-D(-)和一个 prenyleudesmane 型二萜类化合物 lobovarol E()，以及 7 种已知的相关二萜类化合物(-)。基于多种光谱分析和光谱比较确定了它们的结构。本文首次报道了已知化合物的 C-16 的绝对构型。通过测量对 -formyl-methionyl-leucyl-phenyl-alanine/cytochalasin B(fMLP/CB)-诱导的超氧阴离子生成和人嗜中性粒细胞弹性蛋白酶释放的抑制作用，评估了化合物-的抗炎活性。发现代谢产物、、和对超氧阴离子的生成具有中等抑制活性，而化合物、、、和在 10 μM 时可有效抑制 fMLP/CB 刺激的人嗜中性粒细胞中弹性蛋白酶的释放。所有分离出的二萜类化合物对一组有限的癌细胞系均没有表现出细胞毒性活性（IC > 50 μM）。
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