Huang Ho-Cheng, Chao Chih-Hua, Kuo Yao-Haur, Sheu Jyh-Horng
Department of Chemical and Materials Engineering, Cheng Shiu University, Kaohsiung, Taiwan.
Chem Biodivers. 2009 Aug;6(8):1232-42. doi: 10.1002/cbdv.200800142.
Seven new polyoxygenated cembranoids possessing an alpha-methylene-gamma-lactone group, crassocolides G-M (1-7, resp.), have been isolated from the AcOEt extract of the Formosan soft coral Sarcophyton crassocaule. The structures of compounds 1-7 were established by detailed spectroscopic analyses, including 2D-NMR spectroscopy ((1)H,(1)H-COSY, HMQC, HMBC, and NOESY), while the absolute configuration of 1 was determined using a modified reaction of Mosher's method. The cytotoxicity of compounds 1-7 against a limited panel of cancer cell lines was also determined.
从台湾软珊瑚厚丛柳珊瑚（Sarcophyton crassocaule）的乙酸乙酯提取物中分离出七种具有α-亚甲基-γ-内酯基团的新多氧化松节藻素，分别为厚丛柳珊瑚素G - M（1 - 7）。通过详细的光谱分析，包括二维核磁共振光谱（（1）H，（1）H-COSY、HMQC、HMBC和NOESY）确定了化合物1 - 7的结构，同时使用改良的莫舍尔方法反应确定了1的绝对构型。还测定了化合物1 - 7对一组有限癌细胞系的细胞毒性。
