Sağlam Beyhan, Cikler Esra, Zeybek Ali, Cetinel Sule, Sener Göksel, Ercan Feriha
Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey.
BJU Int. 2006 Dec;98(6):1250-4. doi: 10.1111/j.1464-410X.2006.06511.x.
To investigate the role of aqueous garlic extract (AGE) on the water-avoidance stress (WAS)-induced degeneration of the urinary bladder in a rat model.
Wistar albino rats were exposed to WAS for 2 h/day for 5 days (WAS group), after which, AGE (1 mL/kg) was injected intraperitoneally into the rats (WAS + AGE group). Urinary bladder samples were investigated with both light and scanning electron microscopy, and lipid peroxidation and glutathione levels were also measured in the samples.
In the WAS group there was inflammatory cell infiltration, more mast cells and ulcerated areas in the mucosa. In the WAS + AGE group there was relatively normal urothelial alignment, moderate inflammatory cell infiltration and fewer mast cells in the mucosa. The increased lipid peroxidation and decreased glutathione levels in WAS rats were reversed by AGE treatment.
These results show that AGE has a protective effect on WAS-induced degenerative changes in the urinary bladder.
在大鼠模型中研究大蒜水提取物（AGE）对水回避应激（WAS）诱导的膀胱退变的作用。
将Wistar白化大鼠每天暴露于WAS环境2小时，持续5天（WAS组），之后，将AGE（1 mL/kg）腹腔注射到大鼠体内（WAS + AGE组）。用光镜和扫描电子显微镜对膀胱样本进行研究，并测量样本中的脂质过氧化和谷胱甘肽水平。
WAS组出现炎症细胞浸润，黏膜中有更多肥大细胞和溃疡区域。WAS + AGE组尿路上皮排列相对正常，黏膜中有中度炎症细胞浸润且肥大细胞较少。AGE治疗逆转了WAS大鼠脂质过氧化增加和谷胱甘肽水平降低的情况。
这些结果表明，AGE对WAS诱导的膀胱退行性变化具有保护作用。
