Schweitzer A N, Taylor D W
Department of Pathology, University of Cambridge.
Parasite Immunol. 1991 May;13(3):261-76. doi: 10.1111/j.1365-3024.1991.tb00281.x.
The previously observed MHC-restriction of the antibody response to an 86kDa S. mansoni antigen has been investigated in more detail. The I-A locus of the H-2 complex has been implicated as conferring responder or non-responder status on mice expressing the k and b alleles respectively. Inheritance of responsiveness was dominant over non-responsiveness. An additional level of complexity was observed in the p86 antibody responder status of individuals within a responding inbred strain. This could not be accounted for directly by the level of patent infection, but showed an inverse correlation with the level of egg output in H-2k mice. Differential antibody responsiveness to other antigens, between individuals of the same strain, occurred independently of the differential responsiveness to p86.
之前观察到的针对曼氏血吸虫86kDa抗原的抗体反应的MHC限制已得到更详细的研究。H-2复合体的I-A基因座分别被认为赋予了表达k和b等位基因的小鼠反应者或无反应者状态。反应性的遗传对无反应性呈显性。在一个反应性近交系内个体的p86抗体反应者状态中观察到了额外的复杂程度。这不能直接由显性感染水平来解释，但在H-2k小鼠中与产卵量水平呈负相关。同一品系个体之间对其他抗原的不同抗体反应性独立于对p86的不同反应性而发生。
