Kuba M, Kubová Z, Kremlácek J, Langrová J
Electrophysiological Laboratory, Department of Pathophysiology, Charles University in Prague, Faculty of Medicine in Hradec Králové, Simkova 870, 500 38 Hradec Králové, Czech Republic.
Vision Res. 2007 Jan;47(2):189-202. doi: 10.1016/j.visres.2006.09.020. Epub 2006 Nov 28.
This review article summarises the research on the motion-onset visual evoked potentials (VEPs) and important motion stimulus parameters which have been clarified. For activation of the visual motion processing system and evocation of the motion-onset specific N2 peak (with latency of 160-200ms) from the extra-striate temporo-occipital and/or parietal cortex, the following stimulus parameters can be recently recommended: low luminance (<ca. 20cd/m(2)) and low contrast (<ca. 10%-sinusoidally modulated) of a moving structure with low velocity and temporal frequency (<ca. 6Hz). A short (up to 200ms) duration of motion and a long (at least 1s) inter-stimulus interval reduce adaptation to motion and predominance of a pattern-related P1 peak. Radial motion (with increasing velocity and decreasing spatial frequency towards the periphery) produces larger reactions as compared to a unidirectional translation. In view of the slow maturation (up to the age of 18 years) and early ageing of the visual motion processing system, the use of age-dependent latency norms may be necessary. Since early or selective involvement of the motion processing system is suspected in some CNS disorders, we suggest an evaluation of the utility of motion-onset VEPs as part of the electrophysiological CNS examination since this method may recognise motion processing involvement better than other methods. Motion-onset VEPs might increase the sensitivity of this examination for diagnosing CNS diseases including Multiple Sclerosis, Neuroborreliosis, Glaucoma, Dyslexia and Encephalopathies.
这篇综述文章总结了关于运动起始视觉诱发电位（VEP）的研究以及已明确的重要运动刺激参数。为激活视觉运动处理系统并从颞枕叶和/或顶叶皮质诱发运动起始特异性N2峰（潜伏期为160 - 200毫秒），最近可推荐以下刺激参数：低亮度（<约20cd/m²）、低对比度（<约10% - 正弦调制）、低速度和时间频率（<约6Hz）的运动结构。短时间（最长200毫秒）的运动和长的刺激间隔（至少1秒）可减少对运动的适应以及与图案相关的P1峰的优势。与单向平移相比，径向运动（速度增加且空间频率向周边降低）会产生更大的反应。鉴于视觉运动处理系统成熟缓慢（直至18岁）且早期老化，可能有必要使用与年龄相关的潜伏期标准。由于怀疑在某些中枢神经系统疾病中运动处理系统会早期或选择性受累，我们建议将运动起始VEP的效用评估作为中枢神经系统电生理检查的一部分，因为这种方法可能比其他方法更能识别运动处理受累情况。运动起始VEP可能会提高该检查对诊断包括多发性硬化症、神经莱姆病、青光眼、诵读困难和脑病在内的中枢神经系统疾病的敏感性。
