Rode G, Michel C, Rossetti Y, Boisson D, Vallar G
Université de Lyon, Université Lyon 1, Inserm UMR-S 534, Bron, France.
Neurology. 2006 Nov 28;67(10):1801-8. doi: 10.1212/01.wnl.0000244432.91915.d0.
To quantitate a size distortion involving the side of space contralateral to the lesion (contralesional) in two right-brain-damaged patients.
We studied two right-brain-damaged patients with lesions sparing the occipital lobe and a mild left neglect on target cancellation or line bisection. The lesions involved the temporoparietal region (Patient 1) and the basal ganglia and the insula (Patients 1 and 2). Patients were given drawing tasks and tasks requiring perceptual and visuomotor judgments of horizontal extent.
In drawing objects such as a daisy both from memory and by copying, patients exhibited a disproportionate enlargement of the left-hand side of objects and added more left-sided petals to the drawn daisy. This pathologic behavior persisted when the patients were blindfolded and was likely to reflect a perceptual, rather than premotor, size distortion. In a task requiring the perceptual matching of two rectangles, patients underestimated the left-sided stimulus. In a visuomotor task requiring the reproduction of the horizontal extent of a segment, patients exhibited a hyperextension, when a leftward movement was required.
We showed a disordered representation of extrapersonal space, possibly involving a contralesional relaxation of the spatial medium. The deficit does not arise at the level of retinotopic coordinate frames and is independent of unilateral spatial neglect.
对两名右脑损伤患者中涉及损伤对侧空间（对侧）的大小失真进行量化。
我们研究了两名右脑损伤患者，其损伤未累及枕叶，在目标消除或直线二等分任务中存在轻度左侧忽视。损伤累及颞顶叶区域（患者1）以及基底神经节和脑岛（患者1和患者2）。患者接受绘画任务以及需要对水平范围进行感知和视觉运动判断的任务。
在凭记忆和临摹绘制雏菊等物体时，患者绘制的物体左侧出现不成比例的放大，并且在绘制的雏菊上添加了更多左侧花瓣。当患者被蒙上眼睛时，这种病理行为仍然存在，并且可能反映了一种感知上的而非运动前的大小失真。在一项需要对两个矩形进行感知匹配的任务中，患者低估了左侧刺激。在一项需要再现线段水平范围的视觉运动任务中，当需要向左移动时，患者表现出过度伸展。
我们展示了个人空间外空间的无序表征，可能涉及对侧空间介质的松弛。这种缺陷并非出现在视网膜坐标框架层面，并且与单侧空间忽视无关。
