Demina A A, Semina N A, Trofimova N P, Igonina Y A, Gracheva A M
J Hyg Epidemiol Microbiol Immunol. 1975;19(3):293-304.
The results of the study revealed correlation between the reactogenicity of pertussis vaccines in epidemiological observations and the toxic properties of pertussis bacteria in experiment. Quantitative and qualitative differences were found between the toxic factors in pertussis bacteria depending on their type-specific serological activity. Serotype 1.0.3 microbes exhibit more pronounced toxicity which accounts for the greater reactogenicity of vaccines prepared from this serotype as compared with the preparation produced from the serotype 1.2.3. The obtained results suggest the necessity of considering the greater toxicity of the serotype 1.0.3 in the preparation of pertussis vaccines.
该研究结果揭示了百日咳疫苗在流行病学观察中的反应原性与实验中百日咳杆菌毒性特性之间的相关性。根据百日咳杆菌的型特异性血清学活性，发现其毒性因子存在数量和质量上的差异。1.0.3血清型微生物表现出更明显的毒性，这解释了与1.2.3血清型制备的疫苗相比，由该血清型制备的疫苗具有更高的反应原性。所得结果表明，在制备百日咳疫苗时，有必要考虑1.0.3血清型的更高毒性。
