Chuprinina R P
Zh Mikrobiol Epidemiol Immunobiol. 1975 Sep;0(9):111-6.
The author presents materials concerning the study of the toxic properties of 12 pertussis cultures used in the USSR for the production of vaccines. As a result of studying the toxic properties of the microbes in the test of the change of the weight of mice, and in experiments of testing the anaphylactogenic and histamine-sensitizing activities it was revealed that the strains of pertussis microbes differed by the quantitative content in them of the thermolabile toxin, endotoxin, lymphocytosis-stimulating and histamine-sensitizing factors; therefore, the period of keeping the pertussis suspensions for 1.5 months from the moment of detoxication proved to be inadequate for some of the strains. Since the toxic properties of the strains failed to correlate with their protective activity, in recommendation of pertussis strains for the production of pertussis vaccine preference should be given to the strains with lesser toxic properties.
作者介绍了有关苏联用于生产疫苗的12种百日咳培养物毒性特性研究的材料。通过在小鼠体重变化试验中研究微生物的毒性特性，以及在测试过敏反应原性和组胺致敏活性的实验中发现，百日咳微生物菌株在不耐热毒素、内毒素、淋巴细胞增多刺激因子和组胺致敏因子的定量含量上存在差异；因此，从脱毒时刻起将百日咳悬液保存1.5个月的时间对某些菌株来说是不够的。由于菌株的毒性特性与其保护活性不相关，在推荐用于生产百日咳疫苗的百日咳菌株时，应优先选择毒性较小的菌株。
