Autti-Rämö I, Granström M L
Department of Child Neurology, University of Helsinki, Finland.
Neuropediatrics. 1991 May;22(2):59-64. doi: 10.1055/s-2008-1071418.
The developmental abilities of 80 children exposed to alcohol of various duration in utero were assessed 1 to 3 times during their first year of life. The occurrence of developmental delay increased towards the end of the first year. The longer the exposure the more common and severe was the developmental delay. If alcohol consumption could be reduced by the second trimester only a slight abnormality of motor development was seen at the age of 12 months. If heavy maternal drinking continued throughout the second trimester cognitive development was also delayed. Psychomotor retardation by the age of one year occurred in 38% of children who had been exposed to continuous heavy alcohol consumption during pregnancy. The psychomotor retardation diagnosed at the age of one year could be found earlier in 80% of the children but pure motor or pure cognitive delay only in some cases. The beneficial effect of reducing maternal alcohol consumption before the last trimester of the child's development was clear.
对80名在子宫内接触不同时长酒精的儿童在其生命的第一年进行了1至3次发育能力评估。发育迟缓的发生率在第一年快结束时有所增加。接触酒精的时间越长,发育迟缓就越常见且越严重。如果仅在孕中期减少酒精摄入,在12个月大时仅会出现轻微的运动发育异常。如果母亲在整个孕中期持续大量饮酒,认知发育也会延迟。在孕期持续大量饮酒的儿童中,38%在1岁时出现精神运动发育迟缓。在1岁时被诊断出的精神运动发育迟缓在80%的儿童中可更早发现,但纯运动或纯认知延迟仅在某些情况下出现。在孩子发育的最后三个月之前减少母亲酒精摄入的有益效果是明显的。