Taruscio D, Malchiodi Albedi F, Bagnato R, Pauluzzi S, Francisci D, Cavaliere A, Donelli G
Department of Ultrastructure, National Institute of Health, Rome, Italy.
Acta Neuropathol. 1991;81(5):552-6. doi: 10.1007/BF00310137.
To verify how the components of the capillary wall are modified in the course of AIDS we studied the brain cortex from nine cases with AIDS. Cellular and extracellular components were delineated using antibodies for laminin and collagen IV for basement membranes and glial fibrillary acidic protein for astrocyte foot processes. We found a marked increase in reactivity for laminin in the basement membranes of capillary walls and hypertrophy and hyperplasia of astrocyte foot processes around vessels, when compared to control cortical tissue. We suggest that modifications of brain capillary wall may have a role in the pathogenesis of neurological disfunction in AIDS.
为了验证在艾滋病病程中毛细血管壁的成分是如何改变的，我们研究了9例艾滋病患者的大脑皮质。使用针对层粘连蛋白和IV型胶原的抗体来描绘基底膜的细胞和细胞外成分，使用针对胶质纤维酸性蛋白的抗体来描绘星形胶质细胞足突。与对照皮质组织相比，我们发现毛细血管壁基底膜中层粘连蛋白的反应性显著增加，血管周围星形胶质细胞足突肥大和增生。我们认为脑毛细血管壁的改变可能在艾滋病神经功能障碍的发病机制中起作用。
