高效一锅两步微波辅助合成多取代2-氨基咪唑的方法。
Efficient one-pot, two-step, microwave-assisted procedure for the synthesis of polysubstituted 2-aminoimidazoles.
作者信息
Ermolat'ev Denis S, Babaev Eugene V, Van der Eycken Erik V
机构信息
Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium.
出版信息
Org Lett. 2006 Dec 7;8(25):5781-4. doi: 10.1021/ol062421c.
PMID:17134271
Abstract
A microwave-assisted, one-pot, two-step protocol was developed for the construction of polysubstituted 2-aminoimidazoles. This process involves the sequential formation of imidazo[1,2-a]pyrimidinium salts from readily available 2-aminopyrimidines and alpha-bromocarbonyl compounds, followed by opening of the pyrimidine ring with hydrazine. [reaction: see text]
摘要
开发了一种微波辅助的一锅两步法来构建多取代的2-氨基咪唑。该过程包括从易得的2-氨基嘧啶和α-溴代羰基化合物依次形成咪唑并[1,2-a]嘧啶鎓盐，然后用肼打开嘧啶环。[反应：见正文]
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