Camenga D L, Nathanson N
J Neuropathol Exp Neurol. 1975 Nov;34(6):492-500. doi: 10.1097/00005072-197511000-00003.
The effects of immune manipulation upon survival and histopathology in two experimental group B togavirus encephalitides were studied in inbred mice. The median survival time 8 days after intracerebral injection of Langat virus increased to 10 days with an immunosuppressive course of cyclophosphamide, with concomitant reduction in the inflammatory response. Adoptive immunization with immune lymphoid cells or serum also tended to prolong Langat virus survival while increasing inflammation. Survival following intracerebral West Nile virus (7 days) was unaffected by immunosuppression or adoptive transfer, although suppression was associated with less severe CNS lesions, and immune serum with less necrosis. These findings indicate that the immune response may be both protective and pathology-inducing in some togarvirus encephalitides. The differences in host response to these two related agents suggest caution in generalizing about the role of the immune response in viral infections.
在近交系小鼠中研究了免疫调控对两种B组披膜病毒脑炎的生存和组织病理学的影响。脑内注射兰加特病毒8天后的中位生存时间，在接受环磷酰胺免疫抑制疗程后从8天增加到10天，同时炎症反应有所减轻。用免疫淋巴细胞或血清进行过继免疫也倾向于延长兰加特病毒的存活时间，同时增加炎症。脑内注射西尼罗河病毒后的生存时间（7天）不受免疫抑制或过继转移的影响，尽管免疫抑制与不太严重的中枢神经系统病变相关，而免疫血清与较少的坏死相关。这些发现表明，在某些披膜病毒脑炎中，免疫反应可能既具有保护作用又可诱导病变。宿主对这两种相关病原体反应的差异表明，在概括免疫反应在病毒感染中的作用时应谨慎。
