感染虫媒病毒后朗格汉斯细胞的表型变化：在对经表皮获得性病毒感染的免疫反应中起作用？
Phenotypic changes in Langerhans' cells after infection with arboviruses: a role in the immune response to epidermally acquired viral infection?
作者信息
Johnston L J, Halliday G M, King N J
机构信息
Department of Pathology, University of Sydney, Sydney, New South Wales, Australia.
出版信息
J Virol. 1996 Jul;70(7):4761-6. doi: 10.1128/JVI.70.7.4761-4766.1996.
Abstract
The role of Langerhans cells (LC) in the initiation of an immune response to a viral infection remains unclear. In vivo epidermal infection with the arboviruses West Nile virus and Semliki Forest virus significantly increased the expression of major histocompatibility complex class II antigens, CD54, and CD80 on LC. Thus, during an epidermally acquired viral infection, local LC appear to mature to a phenotype approximating that of lymphoid dendritic cells. This change may be important in the activation of naïve T cells and the subsequent clearance of viral infection.
摘要
朗格汉斯细胞（LC）在引发针对病毒感染的免疫反应中所起的作用仍不清楚。用虫媒病毒西尼罗河病毒和Semliki森林病毒进行体内表皮感染，可显著增加LC上主要组织相容性复合体II类抗原、CD54和CD80的表达。因此，在经表皮获得的病毒感染期间，局部LC似乎成熟为近似淋巴样树突状细胞的表型。这种变化可能在未成熟T细胞的激活以及随后病毒感染的清除中起重要作用。
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Phenotypic changes in Langerhans' cells after infection with arboviruses: a role in the immune response to epidermally acquired viral infection?感染虫媒病毒后朗格汉斯细胞的表型变化：在对经表皮获得性病毒感染的免疫反应中起作用？
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