Gumenscheimer Marina, Balkow Sandra, Simon Markus M, Jirillo Emilio, Galanos Chris, Freudenberg Marina A
Max-Planck-Institut für Immunbiologie, Stübeweg 51, 79 108 Freiburg/Br, Germany.
Med Microbiol Immunol. 2007 Jun;196(2):79-88. doi: 10.1007/s00430-006-0030-1. Epub 2006 Nov 29.
We investigated the effect of a primary non-lethal infection with lymphocytic choriomeningitis virus (LCMV) on the course and outcome of a secondary infection with the Gram-negative Salmonella enterica serovar Typhimurium or the Gram-positive Listeria monocytogenes in mice. We found that at each stage of the viral infection the susceptibility of mice to bacterial super-infections changes dramatically and depends also on whether the secondary infection is a Gram-positive or Gram-negative one. The study shows that the outcome of the secondary infection is determined by a delicate balance between the overproduction of and the hypersensitivity to inflammatory cytokines (TNF-alpha and IFN-gamma), as well as by the changes in blood leukocytes occurring in mice in the course of viral infection.
我们研究了淋巴细胞性脉络丛脑膜炎病毒（LCMV）的初次非致死性感染对小鼠继发感染革兰氏阴性鼠伤寒沙门氏菌或革兰氏阳性单核细胞增生李斯特菌的病程及结果的影响。我们发现，在病毒感染的每个阶段，小鼠对细菌叠加感染的易感性都会发生显著变化，并且还取决于继发感染是革兰氏阳性还是革兰氏阴性。该研究表明，继发感染的结果由炎症细胞因子（肿瘤坏死因子-α和干扰素-γ）的过度产生及超敏反应之间的微妙平衡所决定，同时也取决于病毒感染过程中小鼠血液白细胞的变化。
