Esquivel E, Chaussain M, Plouin P, Ponsot G, Arthuis M
Service de Neuropédiatrie, Hôpital St. Vincent de Paul, Paris, France.
Electroencephalogr Clin Neurophysiol. 1991 Aug;79(2):127-32. doi: 10.1016/0013-4694(91)90050-e.
The aim of this study was to compare the effects of a physical exercise test and of voluntary hyperventilation between controls and children with absence epilepsy. Eighteen children (6 controls and 12 epileptics) were studied during rest (R), a maximal physical exercise test (15 min; PE), recovery (REC) and voluntary hyperventilation (3 min; VHPV). EEG and ECG were recorded during the experiment; respiratory parameters were measured to quantify PE; plasma levels of pH, lactate, pyruvate, glucose and antiepileptic drugs were determined. A decrease in the number of absences was observed during PE whereas an increase was observed during VHPV. We found significant positive correlations between the number of children with absences, the total number of absences for each state, frequency of absences per minute and the corresponding mean plasma pH, which demonstrate that the lower the pH is, the fewer absences occur. On the other hand, there was no relationship between the number of absences and the values of other parameters. Relations between variations of the plasma value of the pH, and thus the probable cerebral value of pH, and neuronal excitability are discussed. Our results indicate that children who suffer absence epilepsy should not be discouraged from sport practice.
本研究旨在比较体育锻炼测试和自愿过度换气对对照组儿童和失神癫痫儿童的影响。对18名儿童（6名对照组儿童和12名癫痫患儿）在静息状态（R）、最大体育锻炼测试（15分钟；PE）、恢复阶段（REC）和自愿过度换气阶段（3分钟；VHPV）进行了研究。实验过程中记录脑电图（EEG）和心电图（ECG）；测量呼吸参数以量化体育锻炼；测定血浆pH值、乳酸、丙酮酸、葡萄糖和抗癫痫药物的水平。在体育锻炼测试期间观察到失神发作次数减少，而在自愿过度换气期间观察到发作次数增加。我们发现，失神儿童的数量、每种状态下失神发作的总数、每分钟失神发作的频率与相应的平均血浆pH值之间存在显著的正相关，这表明pH值越低，失神发作次数越少。另一方面，失神发作次数与其他参数的值之间没有关系。本文讨论了血浆pH值变化以及由此可能的脑内pH值与神经元兴奋性之间的关系。我们的结果表明，不应劝阻患有失神癫痫的儿童进行体育锻炼。
