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[用于地中海贫血筛查的常规血液学参数]

[Routine hematologic parameters for thalassemia screening].

作者信息

Schubert S, Christofi Y, Papadatou A

机构信息

Abteilung für Tropenmedizin und Klinische Parasitologie, Medizinisch-Poliklinischen Institutes, Karl-Marx-Universität Leipzig.

出版信息

Folia Haematol Int Mag Klin Morphol Blutforsch. 1990;117(6):867-73.

PMID:1713894
Abstract

There is an evaluation of routine examination of the blood film for the recognition of Thalassaemia (Th.). The results of 100 blood films from each group--Th. major, Th. minor, healthy persons (centre for Thalassaemia "Bishop Makarios"/Nikosia--Cypros)-were analyzed. MCV and MCH were most useful for the recognition of Th. minor. The constellation of increased red blood cells and normal hemoglobin seems to be typical for Th. minor. Haemoglobin and haematocrit are not suited because they were widely normal. Target cells also are not sufficient for screening--they were present only in 10% of Th. minor. To the contrary most values were clearly decreased in Th. major, and target cells were present here in almost 90%.

摘要

对用于识别地中海贫血(Th.)的血涂片常规检查进行了评估。分析了来自每个组(重型地中海贫血、轻型地中海贫血、健康人,来自塞浦路斯尼科西亚“圣马卡里奥斯主教”地中海贫血中心)的100张血涂片结果。平均红细胞体积(MCV)和平均红细胞血红蛋白含量(MCH)对识别轻型地中海贫血最有用。红细胞增多和血红蛋白正常这一组合似乎是轻型地中海贫血的典型特征。血红蛋白和血细胞比容不适合用于筛查,因为它们大多正常。靶形细胞也不足以用于筛查,它们仅在10%的轻型地中海贫血病例中出现。相反,在重型地中海贫血中,大多数指标明显降低,几乎90%的病例中存在靶形细胞。

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