Hinton Pamela S, Rector R Scott, Thomas Tom R
Department of Nutritional Sciences, University of Missouri-Columbia, Columbia, MO 65211, USA.
Metabolism. 2006 Dec;55(12):1616-8. doi: 10.1016/j.metabol.2006.07.023.
We investigated the impact of weight-bearing, aerobic exercise- and diet-induced weight loss on markers of bone turnover during a larger study of changes in metabolic fitness during short-term weight reduction using a repeated-measures, within-subject experimental design. Subjects (N = 19) underwent 6 weeks of energy restriction (reduced by approximately 3140 kJ/d) and aerobic exercise ( approximately 1675 kJ/d, walking or jogging at 60% maximum oxygen consumption) to induce a 5% reduction in body weight. Bone turnover markers and hormones were measured in serum collected at baseline and after 6 weeks of weight loss. Despite a 5% reduction in body weight at week 6, markers of bone formation, osteocalcin, and bone alkaline phosphatase, were significantly increased, and resorption markers, C-terminal cross-links of type I collagen and soluble receptor activator of nuclear factor kappaB ligand, were unchanged after 6 weeks of energy restriction and exercise. The concentration of leptin was significantly reduced after weight loss, but insulin-like growth factor I (IGF-I) and cortisol levels were unaffected. In conclusion, weight-bearing, aerobic exercise training may favorably affect the balance between bone resorption and formation during weight loss.
在一项关于短期体重减轻期间代谢健康变化的大型研究中，我们采用重复测量的受试者内实验设计，研究了负重、有氧运动和饮食诱导的体重减轻对骨转换标志物的影响。受试者（N = 19）进行了6周的能量限制（每天减少约3140千焦）和有氧运动（每天约1675千焦，以最大耗氧量的60%步行或慢跑），以使体重减轻5%。在基线和体重减轻6周后采集的血清中测量骨转换标志物和激素。尽管在第6周体重减轻了5%，但骨形成标志物、骨钙素和骨碱性磷酸酶显著增加，而在能量限制和运动6周后，骨吸收标志物、I型胶原C端交联物和核因子κB受体活化因子配体可溶性受体未发生变化。体重减轻后瘦素浓度显著降低，但胰岛素样生长因子I（IGF-I）和皮质醇水平未受影响。总之，负重有氧运动训练可能有利于在体重减轻期间影响骨吸收和形成之间的平衡。
