Moreira Linda Denise Fernandes, Fronza Fernanda Cerveira A O, Dos Santos Rodrigo Nolasco, Zach Patrícia Lins, Kunii Ilda S, Hayashi Lilian Fukusima, Teixeira Luzimar Raimundo, Kruel Luis Fernando Martins, Castro Marise Lazaretti
Division of Endocrinology, School of Medicine, Federal University of São Paulo/UNIFESP, São Paulo, Brazil,
J Bone Miner Metab. 2014 Jul;32(4):411-9. doi: 10.1007/s00774-013-0509-y. Epub 2013 Sep 19.
This study aimed to evaluate the 24-week effects of a high-intensity aquatic exercise program on bone remodeling markers and bone mass of postmenopausal women. In this randomized, controlled trial we studied 108 women (58.8 ± 6.4 years), randomized into Aquatic Exercise Group (AEG), n = 64, performing 24 weeks of aquatic exercises, and Control Group (CG), n = 44, sedentary. They had their fasting morning blood sample collected for the measures of intact parathyroid hormone (iPTH), procollagen type 1 amino-terminal propeptide (P1NP) and carboxy-terminal cross-linking telopeptide of type I collagen (CTx). Bone mass was measured by dual-energy X-ray absorptiometry before and after the intervention. Participants of both groups received a daily supplementation of 500 mg of elementary calcium and 1,000 IU of vitamin D (cholecalciferol). Results showed an augment in bone formation marker (P1NP) only in the AEG (15.8 %; p = 0.001), and although both groups experienced significant enhancements in bone resorption marker (CTx), this increase was less considerable in the AEG (15 % in the AEG and 29 % in the CG). IPTH was increased by 19 % in the CG (p = 0.003) at the end. The femoral trochanter BMD presented a 1.2 % reduction in the CG (p = 0.009), whereas in the AEG no change was observed (p = 0.069). The proposed aquatic exercise program was efficient in attenuating bone resorption raise and enhancing bone formation, which prevented the participants in the AEG from reducing the femoral trochanter BMD, as happened in the CG.
本研究旨在评估高强度水上运动计划对绝经后女性骨重塑标志物和骨量的24周影响。在这项随机对照试验中，我们研究了108名女性（58.8±6.4岁），随机分为水上运动组（AEG），n = 64，进行24周的水上运动，以及对照组（CG），n = 44，久坐不动。采集她们空腹的早晨血样，用于检测完整甲状旁腺激素（iPTH）、1型前胶原氨基端前肽（P1NP）和I型胶原羧基末端交联端肽（CTx）。在干预前后通过双能X线吸收法测量骨量。两组参与者每天补充500毫克元素钙和1000国际单位维生素D（胆钙化醇）。结果显示，仅在AEG组骨形成标志物（P1NP）有所增加（15.8%；p = 0.001），并且尽管两组的骨吸收标志物（CTx）都有显著提高，但AEG组的增加幅度较小（AEG组为15%，CG组为29%）。最后，CG组的iPTH增加了19%（p = 0.003）。CG组股骨转子骨密度降低了1.2%（p = 0.009），而AEG组未观察到变化（p = 0.069）。所提出的水上运动计划在减轻骨吸收增加和增强骨形成方面是有效的，这使得AEG组的参与者避免了像CG组那样股骨转子骨密度降低。
