Rolland Yves M, Perry Horace M, Patrick Ping, Banks William A, Morley John E
Geriatric Research, Education and Clinical Center, St. Louis VA Medical Center, Saint Louis, MO 63104, USA.
Metabolism. 2006 Dec;55(12):1630-6. doi: 10.1016/j.metabol.2006.07.026.
To investigate the relationships between blood levels of leptin or adiponectin and lifestyle habits, hormones, and inflammatory markers, we measured parameters of alcohol intake, smoking, physical activity, and blood levels of leptin, adiponectin, testosterone, estrone, estradiol, cortisol, dihydroepiandrostenedione, luteinizing hormone, thyroxin, C-reactive protein (CRP), and interleukin 6 and interleukin 2 receptor in 76 healthy middle-aged postmenopausal women. Anthropometric measures and body composition (evaluated by dual-energy x-ray absorptiometry) and lipid profiles were also assessed. By simple regression, leptin correlated positively with fat and lean masses, glucose, triglycerides, low-density lipoprotein cholesterol, and total cholesterol, and negatively with high-density lipoprotein cholesterol. Adioponectin correlated negatively with fat and lean masses and low-density lipoprotein cholesterol, and positively with high-density lipoprotein cholesterol. Leptin concentration was correlated inversely with adiponectin (r = -0.26, P < .05) and positively with CRP (r = 0.56, P < .01). Adiponectin concentration was negatively correlated with time since last alcoholic drink (r = -0.24, P < .05) and CRP (r = -0.27, P < .05) and positively with testosterone level (r = 0.23, P < .05). By multiple regression analysis, leptin concentration was predicted by age (P < .05), testosterone (P < .05), adiponectin (P < .05), CRP (P < .01), and interleukin 6 receptor (P < .01). Adiponectin concentration was predicted by the time since last alcoholic drink (P < .05), testosterone (P < .05), leptin (P < .05), and C-reactive protein (P = .05). Similar results were found when leptin or adiponectin concentration was adjusted for fat mass. These results suggested that levels of leptin and adiponectin in middle-aged postmenopausal women are partially determined by sexual hormones and inflammatory marker levels, and both predicted one another. Moreover, adiponectin level may be modulated by alcohol intake.
为了研究瘦素或脂联素的血液水平与生活习惯、激素及炎症标志物之间的关系，我们测量了76名健康的绝经后中年女性的酒精摄入量、吸烟情况、身体活动参数，以及瘦素、脂联素、睾酮、雌酮、雌二醇、皮质醇、脱氢表雄酮、促黄体生成素、甲状腺素、C反应蛋白（CRP）、白细胞介素6和白细胞介素2受体的血液水平。还评估了人体测量指标、身体成分（通过双能X线吸收法评估）和血脂谱。通过简单回归分析，瘦素与脂肪量、去脂体重、葡萄糖、甘油三酯、低密度脂蛋白胆固醇和总胆固醇呈正相关，与高密度脂蛋白胆固醇呈负相关。脂联素与脂肪量、去脂体重和低密度脂蛋白胆固醇呈负相关，与高密度脂蛋白胆固醇呈正相关。瘦素浓度与脂联素呈负相关（r = -0.26，P < 0.05），与CRP呈正相关（r = 0.56，P < 0.01）。脂联素浓度与上次饮酒后的时间呈负相关（r = -0.24，P < 0.05），与CRP呈负相关（r = -0.27，P < 0.05），与睾酮水平呈正相关（r = 0.23，P < 0.05）。通过多元回归分析，瘦素浓度可由年龄（P < 0.05）、睾酮（P < 0.05）、脂联素（P < 0.05）、CRP（P < 0.01）和白细胞介素6受体（P < 0.01）预测。脂联素浓度可由上次饮酒后的时间（P < 0.05）、睾酮（P < 0.05）、瘦素（P < 0.05）和C反应蛋白（P = 0.05）预测。当对瘦素或脂联素浓度进行脂肪量校正时，发现了类似的结果。这些结果表明，绝经后中年女性的瘦素和脂联素水平部分由性激素和炎症标志物水平决定，且二者相互预测。此外，脂联素水平可能受酒精摄入量的调节。
