Rolland Yves M, Perry Horace M, Patrick Ping, Banks William A, Morley John E
Geriatric Research, Education and Clinical Center, St Louis VA Medical Center, St Louis, MO 63104, USA.
J Gerontol A Biol Sci Med Sci. 2007 Mar;62(3):330-5. doi: 10.1093/gerona/62.3.330.
Different factors may predict loss of appendicular muscle mass (LossAMM) and loss of muscle strength (LossMS). We investigated the relationship between LossAMM or LossMS and baseline anthropometric measures, lifestyle habits, hormones, lipid profiles, and inflammatory markers in 49 healthy postmenopausal women (54.1 +/- 4.3 years) in a 24-36-month prospective study.
We measured parameters of lifestyle habits, anthropometry, lipid profiles, and blood levels of testosterone, estrone, estradiol, cortisol, dihydroepiandrostenedione, luteinizing hormone, intact parathyroid hormone (iPTH), 25-hydroxyvitamin D, thyroxine, leptin, adiponectin, C-reactive protein (CRP), and interleukin-6 and interleukin-2 receptors. Percentage of loss per year of isometric knee extensor strength defined LossMS, and percentage of loss of AMM per year (dual x-ray absorptiometry) defined LossAMM.
The means (standard deviation) for LossMS and LossAMM were 1.17%/y (2.03) and 0.60%/y (0.74) and did not correlate (r = -0.001; p =.99). LossMS correlated negatively with level of physical activity (r = -0.28), femoral BMD (r = -0.30), alcohol consumption (r = -0.30), and luteinizing hormone (r = -0.32) and positively with estrone (r = 0.29) and iPTH (r = 0.32) (each at p <.05). LossAMM correlated negatively with AMM (r = -0.41; p <.01). Stepwise regression analyses showed that LossMS was significantly predicted by baseline physical activity (beta = -0.39) with an explanation of variation of the model (R(2)) of 6%, body mass index (BMI) (-0.40; 3%), high-density lipoprotein cholesterol (-0.29; 3%), estrone (0.32; 6%), iPTH (0.27; 7%), and interleukin-2 receptor (0.32; 5%). LossAMM was predicted by baseline height (0.56; 47%), body mass index (1.04; 83%), AMM (-0.92; 76%), thyroxine (-0.33; 8%), estrone (-0.61; 30%), and dihydroepiandrostenedione (0.44; 28%).
LossMS and LossAMM in young postmenopausal women were not correlated with one another, and were determined by different factors.
不同因素可能预测四肢肌肉量减少（LossAMM）和肌肉力量丧失（LossMS）。在一项为期24 - 36个月的前瞻性研究中，我们调查了49名健康绝经后女性（54.1±4.3岁）中LossAMM或LossMS与基线人体测量指标、生活习惯、激素、血脂谱及炎症标志物之间的关系。
我们测量了生活习惯、人体测量、血脂谱参数以及睾酮、雌酮、雌二醇、皮质醇、脱氢表雄酮、促黄体生成素、全段甲状旁腺激素（iPTH）、25 - 羟基维生素D、甲状腺素、瘦素、脂联素、C反应蛋白（CRP）、白细胞介素 - 6和白细胞介素 - 2受体的血药浓度。每年等长伸膝力量的丧失百分比定义为LossMS，每年AMM的丧失百分比（双能X线吸收法）定义为LossAMM。
LossMS和LossAMM的均值（标准差）分别为1.17%/年（2.03）和0.60%/年（0.74），两者无相关性（r = -0.001；p = 0.99）。LossMS与身体活动水平（r = -0.28）、股骨骨密度（r = -0.30）、饮酒量（r = -0.30）和促黄体生成素（r = -0.32）呈负相关，与雌酮（r = 0.29）和iPTH（r = 0.32）呈正相关（均p < 0.05）。LossAMM与AMM呈负相关（r = -0.41；p < 0.01）。逐步回归分析显示，LossMS由基线身体活动水平（β = -0.39）显著预测，模型变异解释率（R²）为6%，还包括体重指数（BMI）（-0.40；3%）、高密度脂蛋白胆固醇（-0.29；3%）、雌酮（0.32；6%）、iPTH（0.27；7%）和白细胞介素 - 2受体（0.32；5%）。LossAMM由基线身高（0.56；47%）、体重指数（1.04；83%）、AMM（-0.92；76%）、甲状腺素（-0.33；8%）、雌酮（-0.61；30%）和脱氢表雄酮（0.44；28%）预测。
年轻绝经后女性的LossMS和LossAMM彼此不相关，且由不同因素决定。
