Miller Gary D, Jenks Monica Z, Vendela Mandolyn, Norris James L, Muday Gloria K
Department of Health and Exercise Science, Wake Forest University, Reynolda Station, P.O. Box 7868 Winston-Salem, NC 27109, USA.
J Obes. 2012;2012:708505. doi: 10.1155/2012/708505. Epub 2012 Dec 26.
To investigate effects of weight loss on adipokines and health measures in obese older adults with symptomatic knee osteoarthritis.
Participants were randomly assigned to either weight loss (WL) (men: 12, women: 14) or weight stable (WS) group (men: 12, women: 13). WL intervention included meal replacements and structured exercise training. Measurements of leptin, adiponectin, soluble leptin receptor, lifestyle behaviors, and body composition were collected at baseline and 6 months. Univariate analysis of covariance was performed on 6 month variables, and Spearman and partial correlations were made between variables.
Weight loss was 13.0% and 6.7% in WL for men and women, respectively. Women in WL had lower whole body and trunk fat than WS. The leptin : adiponectin ratio was lower for women in WL than WS at 6 months, with no group differences in adipokines for men. Leptin and free leptin index correlated with body fat in both genders at baseline. Interestingly, only women showed reductions in leptin (P < 0.100) and correlations between the percentage change leptin and trunk fat and the percentage changes in free leptin index with total fat and trunk fat. Partial correlations between 6 month adipokines after adjustments for covariates and group/time period show potential multivariate influences.
In the presence of an effective weight loss intervention in older obese adults, there are significant relationships between weight and fat loss and leptin in women, but not men, suggesting gender-specific features of adipokine metabolism in this age group.
探讨体重减轻对有症状的老年肥胖膝骨关节炎患者脂肪因子及健康指标的影响。
参与者被随机分为体重减轻组（WL）（男性12名，女性14名）或体重稳定组（WS）（男性12名，女性13名）。WL干预包括代餐和结构化运动训练。在基线和6个月时收集瘦素、脂联素、可溶性瘦素受体、生活方式行为和身体成分的测量数据。对6个月时的变量进行单因素协方差分析，并对变量进行Spearman相关性分析和偏相关性分析。
WL组男性和女性的体重减轻分别为13.0%和6.7%。WL组女性的全身和躯干脂肪低于WS组。6个月时，WL组女性的瘦素与脂联素比值低于WS组，男性的脂肪因子在两组间无差异。基线时，瘦素和游离瘦素指数在男女两性中均与体脂相关。有趣的是，只有女性的瘦素有所降低（P < 0.100），且瘦素百分比变化与躯干脂肪、游离瘦素指数百分比变化与总脂肪和躯干脂肪之间存在相关性。在对协变量和组/时间段进行调整后，6个月时脂肪因子之间的偏相关性显示出潜在的多变量影响。
在老年肥胖成年人中进行有效的体重减轻干预后，女性的体重和脂肪减少与瘦素之间存在显著关系，而男性则不然，这表明该年龄组脂肪因子代谢存在性别特异性特征。
