Rasool Mahaboobkhan, Sabina Evan Prince, Lavanya Balaji
School of Bio-engineering and Biosciences, Vellore Institute of Technology, Deemed University, Tamilnadu, India.
Biol Pharm Bull. 2006 Dec;29(12):2483-7. doi: 10.1248/bpb.29.2483.
The present study was carried out to evaluate the anti-inflammatory effect of Spirulina fusiformis on adjuvant-induced arthritis in mice. Arthritis was induced by intra dermal injection of complete freund's adjuvant (0.1 ml) into the right hind paw of Swiss albino mice. Spirulina fusiformis (800 mg/kg/b.wt) was orally administered for 8 d (from 11th to 18th day) to arthritic animals after adjuvant injection. The anti-inflammatory activity of Spirulina fusiformis was assessed by measuring paw volume, body weight, levels of lysosomal enzymes, tissue marker enzymes and glycoproteins in control and experimental animals. In adjuvant-induced arthritic animals, the levels of lysosomal enzymes, tissue marker enzymes, glycoproteins and the paw volume were increased significantly. However the body weight was found to be reduced when compared to control animals. Oral administration of Spirulina fusiformis (800 mg/kg/b.wt) significantly altered these above physical and biochemical changes observed in arthritic animals to near normal conditions. Hence results of this study clearly indicate that Spirulina fusiformis has promising anti-inflammatory activity against adjuvant-induced arthritic animals.
本研究旨在评估螺旋藻对佐剂诱导的小鼠关节炎的抗炎作用。通过向瑞士白化小鼠的右后爪皮内注射完全弗氏佐剂（0.1毫升）诱导关节炎。在佐剂注射后，对患关节炎的动物口服螺旋藻（800毫克/千克/体重），持续8天（从第11天至第18天）。通过测量对照动物和实验动物的爪体积、体重、溶酶体酶水平、组织标记酶和糖蛋白来评估螺旋藻的抗炎活性。在佐剂诱导的关节炎动物中，溶酶体酶、组织标记酶、糖蛋白水平和爪体积显著增加。然而，与对照动物相比，体重有所下降。口服螺旋藻（800毫克/千克/体重）显著改变了关节炎动物中上述观察到的物理和生化变化，使其接近正常状态。因此，本研究结果清楚地表明，螺旋藻对佐剂诱导的关节炎动物具有有前景的抗炎活性。
