桔梗根的化学成分

[Chemical constituents from roots of Platycodon grandiflorum].

作者信息

Li Ling-Jun, Liu Zhen-Hua, Chen Yun, Tian Jing-Kui

机构信息

Department of Chinese Medicine Science and Engineering, Zhejiang University, Hangzhou 310028, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2006 Sep;31(18):1506-9.

PMID:17144467

Abstract

OBJECTIVE

To study the chemical constituents from roots of Platycodon grandiflorum.

METHOD

Column chromatography (silica gel, macroporous resin, sephadex LH - 20 and the preparative RP - HPLC were used to isolate the constituents. Their structures were elucidated by physical and spectral data.

RESULT

Eight compounds were isolated and identified as tangeritin (1), 3-O-beta-D-glucopyranosylplatycodigenin methyl ester (2), 3-O-beta-D-glucopyranosylplaticogenic acid A lactone (3), 3-O-beta-D-glucopyranosylplatycodigenin (4), deapio-platyconic acid A lactone (5), deapio-platycodin-D (6), platycoside-G1 (7) and platycoside-E (8).

CONCLUSION

Compounds 1,3 and 5 were isolated from this plant for the first time.

摘要

目的

研究桔梗根的化学成分。

方法

采用柱色谱法（硅胶、大孔树脂、葡聚糖凝胶LH - 20和制备型反相高效液相色谱）分离化合物。通过物理和光谱数据阐明其结构。

结果

分离鉴定出8个化合物，分别为橘红素（1）、3 - O - β - D - 吡喃葡萄糖基桔梗皂苷元甲酯（2）、3 - O - β - D - 吡喃葡萄糖基桔梗酸A内酯（3）、3 - O - β - D - 吡喃葡萄糖基桔梗皂苷元（4）、去芹糖桔梗酸A内酯（5）、去芹糖桔梗皂苷D（6）、桔梗皂苷 - G1（7）和桔梗皂苷 - E（8）。