删除布氏锥虫超氧化物歧化酶基因sodb1会增加对硝呋替莫和苯硝唑的敏感性。
Deletion of the Trypanosoma brucei superoxide dismutase gene sodb1 increases sensitivity to nifurtimox and benznidazole.
作者信息
Prathalingham S Radhika, Wilkinson Shane R, Horn David, Kelly John M
机构信息
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom.
出版信息
Antimicrob Agents Chemother. 2007 Feb;51(2):755-8. doi: 10.1128/AAC.01360-06. Epub 2006 Dec 4.
It has been more than 25 years since it was first reported that nifurtimox and benznidazole promote superoxide production in trypanosomes. However, there has been no direct evidence of an association between the drug-induced free radicals and trypanocidal activity. Here, we identify a superoxide dismutase required to protect Trypanosoma brucei from drug-generated superoxide.
自首次报道硝呋替莫和苯硝唑可促进锥虫产生超氧化物以来，已有25年多的时间。然而，尚无直接证据表明药物诱导的自由基与杀锥虫活性之间存在关联。在此，我们鉴定出一种超氧化物歧化酶，它是保护布氏锥虫免受药物产生的超氧化物伤害所必需的。
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