Frank Diane, Gauthier Audrey, Bergeron Renée
Université de Montréal, Faculté de Médecine Vétéinaire, Centre Hospitalier, Universitaire Vétérinaire, C.P. 5000, Saint-Hyacinthe, Québec.
Can Vet J. 2006 Nov;47(11):1102-8.
The purpose of this explorative study was, first, to document changes in physiological parameters and behavior observed in dogs following ground transport and, second, to measure the effects on the above variables of a short-term administration of clomipramine, anecdotally already prescribed in private veterinary practice to reduce fear, anxiety, or both. Twenty-four beagles were randomly allocated to either clomipramine (2 mg/kg, q12h for 7 d) or placebo treatment, and then transported 3 times in a truck for 1 hour. Physiological parameters (cortisol, neutrophil:lymphocyte (N:L) ratio, heart rate) and behavior were recorded and analyzed. Clomipramine significantly reduced plasma cortisol (P < 0.05) following transport and tended (P = 0.07) to reduce N:L ratio. Clomipramine tended to only reduce "moving and panting" and drooling. Short-term administration of clomipramine appears to slightly reduce fear, anxiety, or both during transport. More research is needed to confirm the efficacy of this treatment and the appropriate dosage.
这项探索性研究的目的，其一，是记录犬只在地面运输后观察到的生理参数和行为变化；其二，是测量短期给予氯米帕明（在私人兽医实践中，已有传闻称使用该药可减轻恐惧、焦虑或两者兼而有之）对上述变量的影响。24只比格犬被随机分配至氯米帕明组（2毫克/千克，每12小时一次，共7天）或安慰剂组，然后用卡车运输3次，每次1小时。记录并分析生理参数（皮质醇、中性粒细胞：淋巴细胞（N:L）比值、心率）和行为。运输后，氯米帕明显著降低了血浆皮质醇水平（P < 0.05），并使N:L比值有降低趋势（P = 0.07）。氯米帕明仅使“走动和喘气”及流口水有减少趋势。短期给予氯米帕明似乎能在运输过程中略微减轻恐惧、焦虑或两者兼而有之。需要更多研究来证实这种治疗方法的疗效和合适剂量。
