Williams J F, Bement W J, Sinclair J F, Sinclair P R
VA Hospital, White River Junction, VT 05009.
Biochem Biophys Res Commun. 1991 Aug 15;178(3):1049-55. doi: 10.1016/0006-291x(91)90998-m.
Human recombinant interleukin 6 (rhIL-6) caused a dose dependent decrease in the phenobarbital induction of benzyloxyresorufin O-deethylase activity in cultured rat hepatocytes. Decreased enzymatic activity was associated with a decrease in the amount of immunoreactive P-450IIB1/2. rhIL-6 also prevented the PB-induced increase in the steady state level of P-450IIB mRNA. These results suggest that altered P-450 levels observed in vivo during the acute phase reaction may be due to interleukin 6.
人重组白细胞介素6（rhIL-6）导致培养的大鼠肝细胞中苯巴比妥诱导的苄氧基试卤灵O-脱乙基酶活性呈剂量依赖性降低。酶活性降低与免疫反应性P-450IIB1/2量的减少有关。rhIL-6还阻止了苯巴比妥诱导的P-450IIB mRNA稳态水平的升高。这些结果表明，急性期反应期间体内观察到的P-450水平改变可能归因于白细胞介素6。
