疟原虫的生长受到蚊子叮咬的刺激。
Malaria parasite growth is stimulated by mosquito probing.
作者信息
Billingsley P F, Snook L S, Johnston V J
机构信息
School of Biological Sciences, University of Aberdeen, Aberdeen, UK.
出版信息
Biol Lett. 2005 Jun 22;1(2):185-9. doi: 10.1098/rsbl.2004.0260.
Abstract
The ability of malaria parasites to respond positively to the presence of feeding mosquito vectors would clearly be advantageous to transmission. In this study, Anopheles stephensi mosquitoes probed mice infected with the rodent malaria parasite, Plasmodium chabaudi. Growth of asexual stages was accelerated and gametocytes appeared 1-2 days earlier than in controls. This first study, to our knowledge, of the effects of mosquitoes on 'in-host' growth and development of Plasmodium has profound implications for malaria epidemiology, suggesting that individuals exposed to high mosquito numbers can contribute disproportionately high numbers of parasites to the transmission pool.
摘要
疟原虫对正在吸血的蚊媒的存在做出积极反应的能力显然对传播有利。在本研究中，斯氏按蚊叮咬感染了啮齿类疟原虫——查巴迪疟原虫的小鼠。无性阶段的生长加速，配子体比对照组提前1 - 2天出现。据我们所知，这是第一项关于蚊子对疟原虫“宿主体内”生长和发育影响的研究，对疟疾流行病学具有深远意义，表明暴露于大量蚊子的个体可能会向传播库贡献不成比例的大量疟原虫。
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