Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.
Front Cell Infect Microbiol. 2021 Dec 2;11:790067. doi: 10.3389/fcimb.2021.790067. eCollection 2021.
Blocking malaria transmission is critical to malaria control programs but remains a major challenge especially in endemic regions with high levels of asymptomatic infections. New strategies targeting the transmissible sexual stages of the parasite, called gametocytes, are needed. This review focuses on gametocytogenesis and . Highlighting advances made elucidating genes required for gametocyte production and identifying key questions that remain unanswered such as the factors and regulatory mechanisms that contribute to gametocyte induction, and the mechanism of sequestration. Tools available to begin to address these issues are also described to facilitate advances in our understanding of this important stage of the life cycle.
阻断疟疾传播对于疟疾控制项目至关重要，但在感染水平较高的地方性流行地区，这仍然是一个主要挑战。需要针对寄生虫可传播的有性阶段（称为配子体）的新策略。本综述重点介绍了配子体发生和。强调了阐明配子体产生所需基因方面的进展，并确定了仍然存在的未解决的关键问题，例如导致配子体诱导的因素和调节机制，以及隔离的机制。还描述了可用于开始解决这些问题的工具，以促进我们对生命周期这一重要阶段的理解的进展。
