乳糜泻与原发性甲状旁腺功能亢进症：有关联吗？
Coeliac disease and primary hyperparathyroidism: an association?
作者信息
Maida M J, Praveen E, Crimmins S R, Swift G L
机构信息
Department of Gastroenterology, Llandough Hospital, Penarth CF64 2XX, UK.
出版信息
Postgrad Med J. 2006 Dec;82(974):833-5. doi: 10.1136/pgmj.2006.045500.
Primary hyperparathyroidism may present with non-specific symptoms, and this may be one reason why patients with coeliac disease fail to improve despite compliance with a gluten-free diet. Seven case reports of primary hyperparathyroidism due to sporadic adenoma occurring in a series of 310 patients with coeliac disease are presented, highlighting the importance of looking for this condition in this population group. A prevalence of primary hyperparathyroidism of 2.3% in this series suggests a significant association between hyperparathyroidism and coeliac disease; most studies have indicated a prevalence of 3 in 1000 in the general population, although one study found that it may be as high as 21 in 1000 in women aged 55-75 years. The average age of patients in our series was 59 years and all but one were women. Further studies are needed to establish a possible association between primary hyperparathyroidism and coeliac disease.
原发性甲状旁腺功能亢进可能表现为非特异性症状，这可能是乳糜泻患者尽管遵循无麸质饮食但病情仍未改善的原因之一。本文报告了310例乳糜泻患者中因散发性腺瘤导致原发性甲状旁腺功能亢进的7个病例，强调了在该人群中筛查这种疾病的重要性。该系列中原发性甲状旁腺功能亢进的患病率为2.3%，提示甲状旁腺功能亢进与乳糜泻之间存在显著关联；大多数研究表明，普通人群中的患病率为千分之三，不过有一项研究发现，在55至75岁的女性中，患病率可能高达千分之二十一。我们系列研究中的患者平均年龄为59岁，除1例男性外均为女性。需要进一步研究以确定原发性甲状旁腺功能亢进与乳糜泻之间可能存在的关联。
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