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Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert.寻找具有潜在抗癌活性的热休克蛋白90（Hsp90）抑制剂：从索诺兰沙漠的两种植物相关真菌中分离出萝卜素和单青霉素I并进行构效关系研究
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曲霉吡喃酮D及植物相关真菌菌株土曲霉的其他代谢产物。

Asperpyrone D and other metabolites of the plant-associated fungal strain Aspergillus tubingensis.

作者信息

Zhan Jixun, Gunaherath G M Kamal B, Wijeratne E M Kithsiri, Gunatilaka A A Leslie

机构信息

Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, 250 East Valencia Road, Tucson, AZ 85706-6800, USA.

出版信息

Phytochemistry. 2007 Feb;68(3):368-72. doi: 10.1016/j.phytochem.2006.09.038. Epub 2006 Dec 5.

DOI:10.1016/j.phytochem.2006.09.038
PMID:17150233
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3361907/
Abstract

Bioactivity-guided fractionation of a cytotoxic extract of Aspergillus tubingensis, a fungal strain occurring in the rhizosphere of the Sonoran desert plant, Fallugia paradoxa, afforded a dimeric naphtho-gamma-pyrone asperpyrone D, nine known naphtho-gamma-pyrones, funalenone, and the cytotoxic cyclic penta-peptide, malformin A1.

摘要

对一株生长在索诺兰沙漠植物奇异福禄草根际的真菌——管囊曲霉的细胞毒性提取物进行生物活性导向分离，得到了一种二聚萘并γ-吡喃酮曲霉吡喃酮D、九种已知的萘并γ-吡喃酮、富纳雷酮以及细胞毒性环状五肽马尔福菌素A1。