Laboratoire de Génie Chimique, UMR 5503 CNRS/INPT/UPS, Université de Toulouse, INP-ENSAT, 1, avenue de l'Agrobiopôle, 31326, Castanet-Tolosan, France.
Appl Microbiol Biotechnol. 2015 Feb;99(3):1081-96. doi: 10.1007/s00253-014-6295-1. Epub 2014 Dec 19.
Naphtho-γ-pyrones (NGPs) are secondary metabolites mainly produced by filamentous fungi (Fusarium sp., Aspergillus sp.) that should be considered by industrials. Indeed, these natural biomolecules show various biological activities: anti-oxidant, anti-microbial, anti-cancer, anti-HIV, anti-hyperuricuric, anti-tubercular, or mammalian triacylglycerol synthesis inhibition which could be useful for pharmaceutical, cosmetic, and/or food industries. In this review, we draw an overview on the interest in studying fungal NGPs by presenting their biological activities and their potential values for industrials, their biochemical properties, and what is currently known on their biosynthetic pathway. Finally, we will present what remains to be discovered about NGPs.
萘并-γ-吡喃酮（NGPs）是主要由丝状真菌（镰刀菌属、曲霉属）产生的次生代谢物，应该引起工业界的重视。这些天然生物分子具有多种生物活性，如抗氧化、抗菌、抗癌、抗 HIV、抗高尿酸血症、抗结核和抑制哺乳动物三酰基甘油合成等，可用于制药、化妆品和/或食品工业。在本文中，我们通过介绍真菌 NGPs 的生物活性及其对工业界的潜在价值、生化特性以及目前已知的生物合成途径，概述了对其研究的意义。最后，我们将介绍 NGPs 仍有待发现的方面。
