3-硝基丙酸（3-NPA），一种来自内生真菌的强效抗分枝杆菌剂：某些植物中的3-NPA是由内生菌产生的吗？
3-Nitropropionic acid (3-NPA), a potent antimycobacterial agent from endophytic fungi: is 3-NPA in some plants produced by endophytes?
作者信息
Chomcheon Porntep, Wiyakrutta Suthep, Sriubolmas Nongluksna, Ngamrojanavanich Nattaya, Isarangkul Duangnate, Kittakoop Prasat
机构信息
Program of Biotechnology and Department of Chemistry, Faculty of Science, Chulalongkorn University, Thailand.
出版信息
J Nat Prod. 2005 Jul;68(7):1103-5. doi: 10.1021/np050036a.
3-Nitropropionic acid (3-NPA, 1) was found in extracts of several strains of endophytic fungi. 3-NPA (1) exhibited potent antimycobacterial activity with the minimum inhibition concentration of 3.3 microM, but was inactive against NCI-H187, BC, KB, and Vero cell lines. Endophytes were found to produce high levels of 3-NPA (1), and therefore 3-NPA (1) accumulated in certain plants may be produced by the associated endophytes. 3-NPA (1) may be used as a chemotaxonomic marker for endophytic fungi. The structure of 3-hydroxypropionic acid, a nematicidal agent, should be revised to 3-NPA (1).
在几种内生真菌菌株的提取物中发现了3-硝基丙酸（3-NPA，1）。3-NPA（1）表现出强大的抗分枝杆菌活性，最低抑菌浓度为3.3微摩尔，但对NCI-H187、BC、KB和Vero细胞系无活性。发现内生菌能产生高水平的3-NPA（1），因此某些植物中积累的3-NPA（1）可能是由相关内生菌产生的。3-NPA（1）可作为内生真菌的化学分类标记。杀线虫剂3-羟基丙酸的结构应修订为3-NPA（1）。
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