Terato Hiroaki, Tanaka Ruri, Nakaarai Yusuke, Furusawa Yoshiya, Ide Hiroshi
Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, Higashi-Hiroshima 739-8526, Japan.
Nucleic Acids Symp Ser (Oxf). 2004(48):145-6. doi: 10.1093/nass/48.1.145.
Ionizing radiation generates isolated and localized multiple (i.e., clustered) lesions in DNA, and the latter is believed to be primarily responsible for deleterious biological consequences such as cell killing and mutations. In the present study, we irradiated plasmid and lambda DNA by ionizing radiations with different linear energy transfer (LET) values, and compared the yields of isolated and clustered DNA lesions.
电离辐射会在DNA中产生孤立的、局部的多个（即簇状）损伤，而后者被认为是导致细胞杀伤和突变等有害生物学后果的主要原因。在本研究中，我们用不同线性能量传递（LET）值的电离辐射照射质粒和λ噬菌体DNA，并比较了孤立的和簇状DNA损伤的产额。
