Zeidan Omar A, Stephenson Stacy Ann L, Meeks Sanford L, Wagner Thomas H, Willoughby Twyla R, Kupelian Patrick A, Langen Katja M
Department of Radiation Physics, M. D. Anderson Cancer Center Orlando, 1400 South Orange Avenue, MP 730, Orlando, Florida 32806, USA.
Med Phys. 2006 Nov;33(11):4064-72. doi: 10.1118/1.2360012.
We present an evaluation of a new and improved radiochromic film, type EBT, for its implementation to IMRT dose verification. Using a characterized flat bed color CCD scanner, the film's dose sensitivity, uniformity, and speed of development post exposure were shown to be superior to previous types of radiochromic films. The film's dose response was found to be very similar to ion chamber scans in water through comparisons of depth dose and lateral dose profiles. The effect of EBT film polarization with delivered dose and film scan orientation was shown to have a significant effect on the scanner's OD readout. In addition, the film's large size, flexibility, and the ability to submerge it in water for relatively short periods of time allowed for its use in both water and solid water phantoms to verify TomoTherapy IMRT dose distributions in flat and curved dose planes. Dose verification in 2D was performed on ten IMRT plans (five head and neck and five prostate) by comparing measured EBT dose distributions to TomoTherapy treatment planning system calculated dose. The quality of agreement was quantified by the gamma index for four sets of dose difference and distance to agreement criteria. Based on this study, we show that EBT film has several favorable features that allow for its use in routine IMRT patient-specific QA.
我们对一种新型改良的放射变色胶片EBT型进行了评估,以用于调强放射治疗(IMRT)的剂量验证。使用经过特性描述的平板彩色电荷耦合器件(CCD)扫描仪,结果表明该胶片的剂量敏感性、均匀性以及曝光后显影速度均优于以往类型的放射变色胶片。通过比较深度剂量和侧向剂量分布曲线,发现该胶片的剂量响应与水中电离室扫描结果非常相似。EBT胶片的偏振对所传递剂量和胶片扫描方向的影响,被证明对扫描仪的光密度(OD)读数有显著影响。此外,该胶片尺寸大、柔韧性好,并且能够在水中短时间浸泡,这使得它可用于水模体和固体水模体,以验证在平面和曲面剂量平面中的螺旋断层放疗(TomoTherapy)IMRT剂量分布。通过将测量的EBT剂量分布与TomoTherapy治疗计划系统计算的剂量进行比较,对十个IMRT计划(五个头颈部计划和五个前列腺计划)进行了二维剂量验证。通过伽马指数对四组剂量差异和一致性距离标准进行量化,以确定一致性质量。基于这项研究,我们表明EBT胶片具有几个有利特性,使其可用于常规的IMRT患者特定质量保证(QA)。