Mittal Apoorva, Verma Shalini, Natanasabapathi Gopishankar, Kumar Pratik, Verma Akhilesh K
Department of Medical Physics, Dr. B. R. A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi 110029, India.
Department of Chemistry, University of Delhi, Delhi 110007, India.
ACS Omega. 2021 Mar 29;6(14):9482-9491. doi: 10.1021/acsomega.0c06184. eCollection 2021 Apr 13.
Blood and its cellular components are irradiated by ionizing radiation before transfusion to prevent the proliferation of viable T lymphocytes which cause transfusion associated-graft versus host disease. The immunodeficient patients undergoing chemotherapy for various malignancies are at risk of this disease. The international guidelines for blood transfusion recommend a minimum radiation exposure of 25 Gray (Gy) to the midplane of the blood bag, while a minimum dose of 15 Gy and a maximum dose of 50 Gy should be given to each portion of the blood bag. Therefore, precise dosimetry of the blood irradiator is essential to ensure the adequate irradiation of the blood components. The paper presents the fabrication of diacetylene-based colorimetric film dosimeters for the verification of irradiated doses. The diacetylene analogues are synthesized by tailoring them with different amide-based headgroups followed by their coating to develop colorimetric film dosimeters. Among all the synthesized diacetylene analogues, aminofluorene-substituted diacetylene exhibits the most significant color transition from white to blue color at a minimum γ radiation dose of 5 Gy. The quantitative study of color change is performed by the digitization of the scanned images of film dosimeters. The digital image processing of the developed film dosimeters facilitates rapid dose measurement which enables their facile implementation and promising application in routine blood irradiator dosimetry.
输血前，血液及其细胞成分需接受电离辐射，以防止可导致输血相关移植物抗宿主病的存活T淋巴细胞增殖。接受各种恶性肿瘤化疗的免疫缺陷患者有患此病的风险。国际输血指南建议，血袋中平面的最小辐射剂量为25戈瑞（Gy），而血袋各部分的最小剂量应为15 Gy，最大剂量应为50 Gy。因此，血液辐照器的精确剂量测定对于确保血液成分得到充分辐照至关重要。本文介绍了用于验证辐照剂量的基于双乙炔的比色膜剂量计的制作。通过用不同的酰胺基头基对双乙炔类似物进行定制合成，然后将其涂层以开发比色膜剂量计。在所有合成的双乙炔类似物中，氨基芴取代的双乙炔在最低γ辐射剂量为5 Gy时表现出从白色到蓝色最显著的颜色转变。通过对膜剂量计扫描图像进行数字化处理来进行颜色变化的定量研究。所开发的膜剂量计的数字图像处理有助于快速剂量测量，这使其能够在常规血液辐照器剂量测定中轻松实施并具有广阔的应用前景。
