兔和大鼠肺中缺乏二胺氧化酶活性。
Absence of diamine oxidase activity from rabbit and rat lungs.
作者信息
Rao S B, Rao K S, Mehendale H M
出版信息
Biochem J. 1986 Mar 15;234(3):733-6. doi: 10.1042/bj2340733.
Abstract
To study the presence of diamine oxidase (DAO) activity in any tissue with putrescine as the substrate, it is necessary to use inhibitors to block all pathways that could further metabolize gamma-aminobutyraldehyde, which is the product of enzyme reaction. It is also necessary to inhibit any enzyme that may convert putrescine into higher polyamines. By this approach it was observed that lung tissue of both rat and rabbit exhibited no DAO activity. DAO activity was observed in the rat and rabbit intestine, the former showing 3 times as much activity as the latter. The other potential pathways of putrescine metabolism are of no consequence in the rat and rabbit intestine and lungs.
摘要
要以腐胺为底物研究任何组织中二胺氧化酶（DAO）的活性，有必要使用抑制剂来阻断所有可能进一步代谢γ-氨基丁醛的途径，γ-氨基丁醛是酶反应的产物。还必须抑制任何可能将腐胺转化为高级多胺的酶。通过这种方法观察到，大鼠和兔子的肺组织均未表现出DAO活性。在大鼠和兔子的肠道中观察到了DAO活性，前者的活性是后者的3倍。腐胺代谢的其他潜在途径在大鼠和兔子的肠道及肺中无关紧要。
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