肺癌死亡率与炭黑暴露：德国一家炭黑生产厂的巢式病例对照研究。
Lung cancer mortality and carbon black exposure: a nested case-control study at a German carbon black production plant.
作者信息
Büchte Sebastian F, Morfeld Peter, Wellmann Jürgen, Bolm-Audorff Ulrich, McCunney Robert J, Piekarski Claus
机构信息
Institut und Poliklinik für Arbeitsmedizin, Sozialmedizin und Sozialhygiene der Universität zu Köln, Cologne, Germany.
出版信息
J Occup Environ Med. 2006 Dec;48(12):1242-52. doi: 10.1097/01.jom.0000215710.17519.cd.
OBJECTIVE
The objective of this study was to conduct a case-control study of lung cancer nested within a cohort of 1528 German carbon black workers, 1976-1998.
METHODS
The authors conducted risk-set sampling of two controls matched on year of birth and conditional logistic regression modeling of cumulative carbon black exposure, duration of work in different departments, feedstock contact, asbestos exposure, smoking, age at hire, exposures before the carbon black job, and serving as a soldier in World War II or being a prisoner of war. Analyses were performed with both the full cohort and members of an inception cohort subset. Exposures were lagged by 10 years.
RESULTS
Analysis of 50 lung cancer deaths showed no association to carbon black exposure.
CONCLUSIONS
Carbon black exposure was not linked to lung cancer risk. Suggestions of positive associations with asbestos exposure, feedstock contact, and work in specific departments are inconclusive due to small numbers.
目的
本研究的目的是在1976年至1998年的1528名德国炭黑工人队列中进行一项肺癌病例对照研究。
方法
作者进行了风险集抽样，选取了两名在出生年份上匹配的对照，并对累积炭黑暴露、在不同部门的工作时长、原料接触、石棉暴露、吸烟、入职年龄、炭黑工作之前的暴露以及在第二次世界大战中服役或成为战俘等因素进行了条件逻辑回归建模。对整个队列和初始队列子集的成员都进行了分析。暴露滞后10年。
结果
对50例肺癌死亡病例的分析显示，肺癌与炭黑暴露之间无关联。
结论
炭黑暴露与肺癌风险无关。由于数量较少，关于与石棉暴露、原料接触以及在特定部门工作呈正相关的建议尚无定论。
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