Dai Yufei, Niu Yong, Duan Huawei, Bassig Bryan A, Ye Meng, Zhang Xiao, Meng Tao, Bin Ping, Jia Xiaowei, Shen Meili, Zhang Rong, Hu Wei, Yang Xiaofa, Vermeulen Roel, Silverman Debra, Rothman Nathaniel, Lan Qing, Yu Shanfa, Zheng Yuxin
Key Laboratory, National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, 100050, China.
Occupational and Environmental Epidemiology Branch, National Cancer Institute, Rockville, Maryland.
Environ Mol Mutagen. 2016 Oct;57(8):615-622. doi: 10.1002/em.22036. Epub 2016 Sep 27.
The International Agency for Research on Cancer has classified carbon black (CB) as a possible (Group 2B) human carcinogen. Given that most CB manufacturing processes result in the emission of various types of chemicals, it is uncertain if the adverse health effects that have been observed in CB-exposed workers are related to CB specifically or are due to other exposures. To address this issue, we conducted a cross-sectional molecular epidemiology study in China of 106 male factory workers who were occupationally exposed to pure CB and 112 unexposed male workers frequency-matched by age and smoking status from the same geographic region. Repeated personal exposure measurements were taken in workers before biological sample collection. Peripheral blood from all workers was used for the complete blood cell count and lymphocyte subsets analysis. Compared to unexposed workers, eosinophil counts in workers exposed to CB were increased by 30.8% (P = 0.07) after adjusting for potential confounders. When stratified by smoking status, statistically significant differences in eosinophils between CB exposed and unexposed workers were only present among never smokers (P = 0.040). Smoking is associated with alterations in various cell counts; however, no significant interaction between CB exposure and smoking status for any cell counts was observed. Given that inflammation, characterized in part by elevated eosinophils in peripheral blood, may be associated with increased cancer risk, our findings provide new biologic insights into the potential relationship between CB exposure and lung carcinogenesis. Environ. Mol. Mutagen. 57:589-604, 2016. © 2016 Wiley Periodicals, Inc.
国际癌症研究机构已将炭黑（CB）列为可能的（2B组）人类致癌物。鉴于大多数炭黑制造过程会排放各种化学物质，因此尚不确定在接触炭黑的工人中观察到的不良健康影响是具体与炭黑有关，还是由于其他暴露所致。为解决这一问题，我们在中国进行了一项横断面分子流行病学研究，研究对象为106名职业性接触纯炭黑的男性工厂工人和112名来自同一地理区域、年龄和吸烟状况频率匹配的未接触男性工人。在采集生物样本前，对工人进行了多次个人暴露测量。所有工人的外周血用于全血细胞计数和淋巴细胞亚群分析。在调整潜在混杂因素后，接触炭黑的工人嗜酸性粒细胞计数比未接触工人增加了30.8%（P = 0.07）。按吸烟状况分层时，接触炭黑和未接触炭黑的工人之间嗜酸性粒细胞的统计学显著差异仅存在于从不吸烟者中（P = 0.040）。吸烟与各种细胞计数的改变有关；然而，未观察到炭黑暴露与吸烟状况对任何细胞计数有显著的相互作用。鉴于炎症部分特征为外周血嗜酸性粒细胞升高，可能与癌症风险增加有关，我们的研究结果为炭黑暴露与肺癌发生之间的潜在关系提供了新的生物学见解。《环境与分子突变》。57:589 - 604，2016年。© 2016威利期刊公司。
