Steven F S, Griffin M M, Maier H, Born A, Zoeller J
Department of Biochemistry and Molecular Biology, School of Biological Sciences, University of Manchester, UK.
Anticancer Res. 1991 May-Jun;11(3):1189-94.
Tumour cells possess cell surface proteases referred to as guanidinobenzoatase (GB) which are closely similar to plasminogen activator. Previous studies have demonstrated different isoenzymic forms of GB on tumour cells and normal cells which can be recognised by cytoplasmic protein inhibitors extracted from frozen sections of appropriate tissues. We now show that normal human serum possesses inhibitors which selectively recognise the isoenzymic forms of GB associated with normal cell surfaces but do not recognise the GB on tumour cell surfaces in frozen sections of tissue obtained from the head and neck regions.
肿瘤细胞具有一种被称为胍基苯甲酸酶（GB）的细胞表面蛋白酶，它与纤溶酶原激活剂极为相似。先前的研究已证实在肿瘤细胞和正常细胞上存在不同的GB同工酶形式，这些形式可被从适当组织的冰冻切片中提取的细胞质蛋白抑制剂识别。我们现在发现，正常人血清中含有一些抑制剂，它们能选择性地识别与正常细胞表面相关的GB同工酶形式，但在从头部和颈部区域获取的组织冰冻切片中，却无法识别肿瘤细胞表面的GB。
