Doberne Y, Levine L S, New M I
Pediatr Res. 1975 Oct;9(10):794-7. doi: 10.1203/00006450-197510000-00010.
Using a newly devised radioligand method for the simultaneous determination of urinary testosterone (T) and androstanediol (Adiol) nine girls with precocious adrenarche were evaluated. In the base-line state average urinary T excretion (1.29 mug/24 hr) and Adiol excretion (1.33 mug/24 hr) were significantly elevated when compared with 15 age-matched controls (0.3 and 0.33 mug/ 24 hr, respectively, P less than 0.001 for both). Adrenocorticotropic hormone (ACTH) infusion performed in five patients with precocious adrenarche produced at least a 50 greater than increase in urinary T excretion in all and a similar increase in Adiol excretion in four of five patients. Dexamethasone administration in the same five patients produced a 25 greater than fall in urinary T excretion in all and a comparable fall in Adiol in four.
采用一种新设计的放射性配体方法同时测定尿睾酮（T）和雄烷二醇（Adiol），对9名性早熟肾上腺功能初现女童进行了评估。在基线状态下，与15名年龄匹配的对照者相比，尿T排泄量平均为（1.29微克/24小时），尿Adiol排泄量平均为（1.33微克/24小时），均显著升高（对照者分别为0.3和0.33微克/24小时，两者P均小于0.001）。对5名性早熟肾上腺功能初现患者进行促肾上腺皮质激素（ACTH）输注后，所有患者尿T排泄量至少增加50%以上，5名患者中有4名尿Adiol排泄量有类似增加。对同一5名患者给予地塞米松后，所有患者尿T排泄量下降25%以上，4名患者尿Adiol排泄量有类似下降。
