Ray P G, Meador K J, Loring D W, Murro A M, Buccafusco J J, Yang X H, Zamrini E Y, Thompson W O, Thompson E E
Department of Neurology, Medical College of Georgia, Augusta 30912.
Electroencephalogr Clin Neurophysiol. 1991 Sep-Oct;80(5):347-51. doi: 10.1016/0168-5597(91)90081-8.
The unusual combination of a normal pattern reversal VEP and a delayed flash VEP has been reported in patients with dementia of Alzheimer's type (DAT). Hyoscine hydrobromide has been reported to produce a similar VEP abnormality in young, healthy subjects. In the present study, we assessed the relative sensitivity of DAT patients and healthy young, middle-aged and elderly subjects to temporary cholinergic blockade. We report VEP latency values following 3 doses of scopolamine and after a peripheral anticholinergic agent. Flash P2 latency was not significantly slower in DAT patients than in the healthy elderly. Scopolamine increased P2 latency in the young controls but did not affect any other group. The pattern reversal P100 was normal in DAT, and a significant increase in latency occurred following scopolamine administration in both the control and patient groups.
据报道，阿尔茨海默型痴呆（DAT）患者存在正常图形翻转视觉诱发电位（VEP）与延迟闪光VEP的异常组合。据报道，氢溴酸东莨菪碱可使年轻健康受试者产生类似的VEP异常。在本研究中，我们评估了DAT患者以及健康的年轻、中年和老年受试者对临时胆碱能阻滞的相对敏感性。我们报告了3剂东莨菪碱和一种外周抗胆碱能药物后的VEP潜伏期值。DAT患者的闪光P2潜伏期并不比健康老年人明显更慢。东莨菪碱增加了年轻对照组的P2潜伏期，但对其他任何组均无影响。DAT患者的图形翻转P100正常，在对照组和患者组中，东莨菪碱给药后潜伏期均显著增加。
