Swanwick G R, Rowan M, Coen R F, O'Mahony D, Lee H, Lawlor B A, Walsh J B, Coakley D
Mercer's Institute for Research on Ageing, St James's Hospital, Dublin, Ireland.
J Neurol Neurosurg Psychiatry. 1996 Jan;60(1):82-6. doi: 10.1136/jnnp.60.1.82.
Current evidence indicates that, on their own, neither flash visual evoked responses (FVEPs) nor event related potentials (ERPs) are sufficiently useful to the clinician in the very early stages of memory dysfunction. However, the possibilities for the combined use of these measures has not been fully explored.
This study examined the clinical utility of combined FVEP and ERP-P300 component latencies as predictive markers in 16 patients with Alzheimer's disease, 15 patients with depression, and 21 control subjects.
There were significant group differences in FVEP P2 latency (P = 0.004) between the controls and both the depressive patients and those with very mild Alzheimer's disease. There were no statistically significant group differences for the ERP component (N2/P300) amplitudes or latencies. The P300 component latency was positively correlated with both the FVEP N2 and FVEP P2 component latencies in the patients with Alzheimer's disease but not in the control subjects or the depressed patients. A discriminant function, using two ERP and two FVEP component measures, gave an overall correct classification rate for dementia of 78%. In this study of very mildly impaired patients the FVEP latencies provided a more sensitive marker for the presence of cognitive dysfunction than P300 latency delay.
The findings support the use of multimodal evoked potentials in the differential diagnosis of very mild Alzheimer's disease and normal aging.
目前的证据表明，就其本身而言，闪光视觉诱发电位（FVEPs）和事件相关电位（ERPs）在记忆功能障碍的极早期阶段对临床医生的帮助都不够大。然而，这些测量方法联合使用的可能性尚未得到充分探索。
本研究检测了联合FVEPs和ERP-P300成分潜伏期作为预测指标在16例阿尔茨海默病患者、15例抑郁症患者和21名对照者中的临床应用价值。
对照组与抑郁症患者及极轻度阿尔茨海默病患者之间在FVEP P2潜伏期存在显著组间差异（P = 0.004）。ERP成分（N2/P300）的波幅或潜伏期无统计学显著组间差异。在阿尔茨海默病患者中，P300成分潜伏期与FVEP N2和FVEP P2成分潜伏期均呈正相关，但在对照组或抑郁症患者中并非如此。使用两种ERP和两种FVEP成分测量的判别函数对痴呆的总体正确分类率为78%。在这项对极轻度受损患者的研究中，FVEP潜伏期比P300潜伏期延迟更能敏感地提示认知功能障碍的存在。
这些发现支持多模式诱发电位在极轻度阿尔茨海默病与正常衰老的鉴别诊断中的应用。
