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Changes in the human visual evoked potential caused by the anticholinergic agent hyoscine hydrobromide: comparison with results in Alzheimer's disease.抗胆碱能药物氢溴酸东莨菪碱引起的人类视觉诱发电位变化：与阿尔茨海默病的结果比较。
J Neurol Neurosurg Psychiatry. 1986 Feb;49(2):175-82. doi: 10.1136/jnnp.49.2.175.
2
Effects of scopolamine on visual evoked potentials in aging and dementia.东莨菪碱对衰老和痴呆患者视觉诱发电位的影响。
Electroencephalogr Clin Neurophysiol. 1991 Sep-Oct;80(5):347-51. doi: 10.1016/0168-5597(91)90081-8.
3
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Comparison of the effects of Alzheimer's disease, normal aging and scopolamine on human transient visual evoked potentials.阿尔茨海默病、正常衰老和东莨菪碱对人类瞬态视觉诱发电位影响的比较。
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Cholinergic modulation of human P3 event-related potentials.人类P3事件相关电位的胆碱能调制
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Visual evoked potentials to flash and pattern reversal stimulation after administration of systemic or topical scopolamine.全身或局部应用东莨菪碱后对闪光和图形翻转刺激的视觉诱发电位
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The functional organization of the basal forebrain cholinergic system in primates and the role of this system in Alzheimer's disease.灵长类动物基底前脑胆碱能系统的功能组织及其在阿尔茨海默病中的作用。
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Specificity of visual evoked potentials alterations in Alzheimer's disease: comparison with normal aging, depression and scopolamine administration in young healthy volunteers.阿尔茨海默病中视觉诱发电位改变的特异性：与正常衰老、抑郁症及年轻健康志愿者使用东莨菪碱的比较
Acta Neurol Belg. 1989 May-Oct;89(3-4):226-7.

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1
Cholinergic modulation of sensory perception and plasticity.胆碱能调制感觉感知和可塑性。
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Comparison of visual evoked potentials and retinal nerve fiber layer thickness in Alzheimer's disease.阿尔茨海默病患者的视觉诱发电位与视网膜神经纤维层厚度比较。
Front Neurol. 2013 Dec 16;4:203. doi: 10.3389/fneur.2013.00203. eCollection 2013.
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Cholinesterase inhibitors affect brain potentials in amnestic mild cognitive impairment.胆碱酯酶抑制剂影响遗忘型轻度认知障碍患者的脑电位。
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4
Visual evoked potentials to flash and pattern reversal stimulation after administration of systemic or topical scopolamine.全身或局部应用东莨菪碱后对闪光和图形翻转刺激的视觉诱发电位
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5
The effect of the muscarinic antagonist scopolamine on regional cerebral blood flow during the performance of a memory task.毒蕈碱拮抗剂东莨菪碱在记忆任务执行过程中对局部脑血流的影响。
Exp Brain Res. 1995;104(2):337-48. doi: 10.1007/BF00242019.
6
Comparison of the effects of Alzheimer's disease, normal aging and scopolamine on human transient visual evoked potentials.阿尔茨海默病、正常衰老和东莨菪碱对人类瞬态视觉诱发电位影响的比较。
Psychopharmacology (Berl). 1990;102(4):535-43. doi: 10.1007/BF02247137.

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Central nervous system effects of hyoscine in man.东莨菪碱对人体中枢神经系统的作用
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Acetylcholine synthesis and glucose oxidation are preserved in human brain obtained shortly after death.乙酰胆碱合成和葡萄糖氧化在人死后不久获取的大脑中得以保留。
Neurosci Lett. 1982 Aug 16;31(2):195-9. doi: 10.1016/0304-3940(82)90116-1.
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A post-mortem study of the cholinergic and GABA systems in senile dementia.老年痴呆症中胆碱能和γ-氨基丁酸系统的尸检研究。
Brain. 1982 Jun;105(Pt 2):313-30. doi: 10.1093/brain/105.2.313.
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Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain.阿尔茨海默病和老年痴呆症：基底前脑神经元的丧失。
Science. 1982 Mar 5;215(4537):1237-9. doi: 10.1126/science.7058341.
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Presenile dementia--the use of the flash and pattern VEP in diagnosis.早老性痴呆——闪光及图形视觉诱发电位在诊断中的应用
Electroencephalogr Clin Neurophysiol. 1984 May;57(5):405-15. doi: 10.1016/0013-4694(84)90069-5.
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Neurotransmitters and CNS disease. Dementia.神经递质与中枢神经系统疾病。痴呆症。
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The ascending cholinergic reticular system: neocortical, olfactory and subcortical projections.上行胆碱能网状系统：新皮质、嗅觉及皮质下投射。
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An analysis of the learning deficit following hyoscine administration to man.对人体使用东莨菪碱后的学习缺陷分析。
Br J Pharmacol. 1973 Oct;49(2):322-7. doi: 10.1111/j.1476-5381.1973.tb08379.x.
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Human memory and the cholinergic system. A relationship to aging?人类记忆与胆碱能系统。与衰老有关系吗？
Arch Neurol. 1974 Feb;30(2):113-21. doi: 10.1001/archneur.1974.00490320001001.
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Acetylcholine and the synaptic transmission of specific impulses to the visual cortex.乙酰胆碱与特定冲动向视觉皮层的突触传递。
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抗胆碱能药物氢溴酸东莨菪碱引起的人类视觉诱发电位变化：与阿尔茨海默病的结果比较。

Changes in the human visual evoked potential caused by the anticholinergic agent hyoscine hydrobromide: comparison with results in Alzheimer's disease.

作者信息

Bajalan A A, Wright C E, van der Vliet V J

出版信息

J Neurol Neurosurg Psychiatry. 1986 Feb;49(2):175-82. doi: 10.1136/jnnp.49.2.175.

DOI:10.1136/jnnp.49.2.175
PMID:3950635
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1028683/
Abstract

The anticholinergic drug hyoscine hydrobromide produced a slowing of the P2 and N3 components of the flash visual evoked potential (VEP) in young normals but did not affect the pattern reversal VEP. These results, which are similar to those found in Alzheimer's disease, could be explained by an underlying defect of the cholinergic system.

摘要

抗胆碱能药物氢溴酸东莨菪碱可使年轻正常人的闪光视觉诱发电位（VEP）的P2和N3成分减慢，但不影响图形翻转VEP。这些结果与在阿尔茨海默病中发现的结果相似，可能是由胆碱能系统的潜在缺陷所解释。